Literature summary extracted from

Romanelli, R.J.; Wood, T.L.
Directing traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses (2008), J. Neurochem., 105, 2055-2068.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.10.1	clathrin	EGFR is internalized classicaly through clathrin-dependent endocytosis	Homo sapiens
2.7.10.1	Epidermal growth factor	high-doses stimulate ubiquitination and endocytosis of EGFR through caveolae in HeLa cells	Homo sapiens

EC Number	Application	Comment	Organism
2.7.10.1	medicine	internatlization and retrograde trafficking of TrkA is required for neuronal survial	Rattus norvegicus
2.7.10.1	medicine	RTKs mediate diverse processes within the developing and adult brain. Trafficking of RTKs is required for the specificity and fidelity of signal transduction and consequent biological responses within neural cells. Segregation of signaling complexes and the appropriate delivery of RTKs to these complexes is highly regulated through mechanisms including receptor-sorting sequences, adaptor proteins, specific ligand-receptor interactions, and lipid raft microdomains	Homo sapiens

EC Number	Protein Variants	Comment	Organism
2.7.10.1	additional information	mutant insulin receptor, has increased binding to insulin in an acidic endosomal environment in a patient with severe insulin resistant diabetes. Receptor mutant is degraded rather than recycled to the plasma membrane	Homo sapiens

EC Number	Inhibitors	Comment	Organism
2.7.10.1	Antibody	monoclonal antibodies for inhibition of IGF-IR alter receptor trafficking by high affinity binding, promoting receptor degradation and consequently preventing human tumor growth in vivo	Homo sapiens
2.7.10.1	additional information	blocking internalization of the IGF-IR results in an attenuation of ERK activation, with no affect on the activation of the PI-3K/Akt pathway	Cricetulus griseus
2.7.10.1	additional information	blocking internalization of the EGFR expressed in HeLa cells decreases ERK activity but also increases protein kinase C activity	Homo sapiens

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.7.10.1	cell surface	nerve growth factor-mediated survival in PC12 cells is associated with surface localized TrkA via the activation of the PI-3K/Akt pathway, whereas internalized TrkA induces nerve growth factor-mediated differentiation via the ERK pathway	Rattus norvegicus	9986	-
2.7.10.1	endosome	PDGFR-beta activates various signaling pathways within endosomes including PI-3K/Akt in human hepatocellular carcinoma cell line	Homo sapiens	5768	-
2.7.10.1	additional information	caveolae	Homo sapiens	-	-
2.7.10.1	plasma membrane	eceptors are internalized within membrane ruffles independent of clathrin (macroendocytosis)	Rattus norvegicus	5886	-
2.7.10.1	plasma membrane	ErbB4 localizes to lipid rafts in a ligand-dependent manner in HEK-293 cells	Homo sapiens	5886	-

EC Number	Organism	UniProt	Comment	Textmining
2.7.10.1	Cricetulus griseus	-	-	-
2.7.10.1	Homo sapiens	-	-	-
2.7.10.1	Rattus norvegicus	P35739	-	-

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.10.1	HEK-293 cell	-	Homo sapiens	-
2.7.10.1	HeLa cell	-	Homo sapiens	-
2.7.10.1	additional information	hepatocellular carcinoma cell line	Homo sapiens	-
2.7.10.1	neuron	-	Homo sapiens	-
2.7.10.1	oligodendrocyte	-	Homo sapiens	-
2.7.10.1	ovary	-	Cricetulus griseus	-
2.7.10.1	PC-12 cell	nerve growth factor-mediated survival is associated with surface localized TrkA via the activation of the PI-3K/Akt pathway, whereas internalized TrkA induces nerve growth factor-mediated differentiation via the ERK pathway	Rattus norvegicus	-

EC Number	Synonyms	Comment	Organism
2.7.10.1	Egfr	-	Homo sapiens
2.7.10.1	epidermal growth factor receptor	-	Homo sapiens
2.7.10.1	ERBB1	-	Homo sapiens
2.7.10.1	ErbB4	-	Homo sapiens
2.7.10.1	FGFR1	-	Homo sapiens
2.7.10.1	FGFR3	-	Homo sapiens
2.7.10.1	fibroblast growth factor receptor	-	Homo sapiens
2.7.10.1	IGF-IR	-	Cricetulus griseus
2.7.10.1	IGF-IR	-	Homo sapiens
2.7.10.1	insulin-like growth factor type I receptor	-	Cricetulus griseus
2.7.10.1	insulin-like growth factor type I receptor	-	Homo sapiens
2.7.10.1	neurotrophin tyrosine receptor kinase	-	Homo sapiens
2.7.10.1	neurotrophin tyrosine receptor kinase	-	Rattus norvegicus
2.7.10.1	p75 neurotrophin receptor	-	Homo sapiens
2.7.10.1	p75NTR	-	Homo sapiens
2.7.10.1	PDGFR-alpha	-	Homo sapiens
2.7.10.1	PDGFR-beta	-	Homo sapiens
2.7.10.1	platelet-derived growth factor receptor	-	Homo sapiens
2.7.10.1	receptor tyrosine kinase	-	Cricetulus griseus
2.7.10.1	receptor tyrosine kinase	-	Homo sapiens
2.7.10.1	receptor tyrosine kinase	-	Rattus norvegicus
2.7.10.1	RTK	-	Cricetulus griseus
2.7.10.1	RTK	-	Homo sapiens
2.7.10.1	RTK	-	Rattus norvegicus
2.7.10.1	TrkA	-	Homo sapiens
2.7.10.1	TrkA	-	Rattus norvegicus
2.7.10.1	trkB	-	Homo sapiens
2.7.10.1	TrkC	-	Homo sapiens