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Literature summary extracted from

  • Jekabsone, A.; Neher, J.J.; Borutaite, V.; Brown, G.C.
    Nitric oxide from neuronal nitric oxide synthase sensitises neurons to hypoxia-induced death via competitive inhibition of cytochrome oxidase (2007), J. Neurochem., 103, 346-356.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.9 medicine hypoxia synergises with NO from neuronal nitric oxide synthase to induce neuronal death via cytochrome oxidase inhibition causing neuronal depolarisation. Neuronal nitric oxide synthase activity sensitises the cells to hypoxic-inhibition of cytochrome oxidase Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 azide uncompetitive inhibitor, inhibits the oxidase activity both in hypoxia and normoxia Rattus norvegicus
7.1.1.9 cyanide
-
 Rattus norvegicus
7.1.1.9 diethylenetriamine-NONOate
-
 Rattus norvegicus
7.1.1.9 NO inhibits cytochrome oxidase in competition with oxygen. Hypoxia (2% O2) markedly inhibits cytochrome oxidase activity (relative to normoxia), and N-4S-4-amino-5-2-aminoethylaminopentyl-N'-nitroguanidine reverses this inhibition in the presence of hypoxia, but has no effect in normoxia Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Rattus norvegicus
-
 Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 additional information neuronal-glial culture Rattus norvegicus
-
7.1.1.9 neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 tetramethyl-phenylenediamine + O2 + H+
-
 Rattus norvegicus ? + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 cytochrome oxidase
-
 Rattus norvegicus