Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Snook, A.E.; Stafford, B.J.; Li, P.; Tan, G.; Huang, L.; Birbe, R.; Schulz, S.; Schnell, M.J.; Thakur, M.; Rothstein, J.L.; Eisenlohr, L.C.; Waldman, S.A.
    Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity (2008), J. Natl. Cancer Inst., 100, 950-961.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.2 expression of the His6-tagged truncated enzyme mutant in CT26 mouse colon cancer cells, subclining in 293T cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.2 additional information construction of a truncated GCC 1-430 construct, GCC ECD, containing the extracellular ligand-binding domain and a C-terminus His6-tag in in colorectal cancer cells using a viral vector, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Mus musculus
-
 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP Mus musculus BALB/c
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Mus musculus Q3UWA6 GCC; Balb/c mice
-
4.6.1.2 Mus musculus BALB/c Q3UWA6 GCC; Balb/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 colonic cancer cell guanylyl cyclase C is a protein that is expressed in the cells that line the normal intestine and by metastatic colorectal cancer cells. Isozyme GCC is universally expressed by primary and metastatic colorectal tumors Mus musculus
-
4.6.1.2 intestine guanylyl cyclase C is a protein that is expressed in the cells that line the normal intestine and by metastatic colorectal cancer cells Mus musculus
-
4.6.1.2 MC-38 cell C57BL/6-derived colorectal cancer cells Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP
-
 Mus musculus BALB/c 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 GCC
-
 Mus musculus
4.6.1.2 guanylyl cyclase C
-
 Mus musculus
4.6.1.2 More GC-C is a member of the particulate guanylyl cyclase family Mus musculus