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Literature summary extracted from

  • Shani, V.; Bromberg, Y.; Sperling, O.; Zoref-Shani, E.
    Involvement of Src Tyrosine Kinases (SFKs) and of Focal Adhesion Kinase (FAK) in the injurious mechanism in rat primary neuronal cultures exposed to chemical ischemia (2009), J. Mol. Neurosci., 37, 50-59.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 additional information FAK is activated by autophosphorylation at Y397 Rattus norvegicus
2.7.10.2 additional information SFK members are activated by phosphorylation and autophosphorylation Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.10.2 125000
-
 determined by SDS-PAGE and Western Blot analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine Rattus norvegicus
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Rattus norvegicus
-
-
-
2.7.10.2 Rattus norvegicus O35346
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.2 phosphoprotein
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 primary culture primary neuronal culture Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine
-
 Rattus norvegicus ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 FAK
-
 Rattus norvegicus
2.7.10.2 focal adhesion kinase
-
 Rattus norvegicus
2.7.10.2 SFK
-
 Rattus norvegicus
2.7.10.2 Src tyrosine kinase
-
 Rattus norvegicus