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Literature summary extracted from

  • Sankaranarayanan, R.; Cherney, M.M.; Cherney, L.T.; Garen, C.R.; Moradian, F.; James, M.N.
    The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzymes catalytic mechanism (2008), J. Mol. Biol., 375, 1052-1063.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.3.3 hanging drop vapor diffusion method, crystal structures of Mtb OTC in orthorhombic and hexagonal form hexagonal form crystals complexed with carbamoyl phosphate and L-norvaline Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.3 L-norvaline competitive Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.3.3 33000
-
 3 * 33000, crystal structure analysis Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.3.3 carbamoyl phosphate + L-ornithine Mycobacterium tuberculosis catalyzes the sixth step in arginine biosynthesis phosphate + citrulline
-
 r
2.1.3.3 carbamoyl phosphate + L-ornithine Mycobacterium tuberculosis H37Rv catalyzes the sixth step in arginine biosynthesis phosphate + citrulline
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.3 Mycobacterium tuberculosis P9WIT9
-
-
2.1.3.3 Mycobacterium tuberculosis H37Rv P9WIT9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.3 carbamoyl phosphate + L-ornithine catalyzes the sixth step in arginine biosynthesis Mycobacterium tuberculosis phosphate + citrulline
-
 r
2.1.3.3 carbamoyl phosphate + L-ornithine catalyzes the sixth step in arginine biosynthesis Mycobacterium tuberculosis H37Rv phosphate + citrulline
-
 r

Subunits

EC Number Subunits Comment Organism
2.1.3.3 hexamer crystal structure analysis, possibly a crystallization artifact Mycobacterium tuberculosis
2.1.3.3 trimer 3 * 33000, crystal structure analysis Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.1.3.3 Mtb OTC
-
 Mycobacterium tuberculosis