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Literature summary extracted from

  • Berardi, F.; Abate, C.; Ferorelli, S.; de Robertis, A.F.; Leopoldo, M.; Colabufo, N.A.; Niso, M.; Perrone, R.
    Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as DELTA8-DELTA7 sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity (2008), J. Med. Chem., 51, 7523-7531.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.3.5 (+)-pentazocine
-
 Homo sapiens
5.3.3.5 (+/-)-ifenprodil
-
 Homo sapiens
5.3.3.5 1,3-di-2-tolylguanidine
-
 Homo sapiens
5.3.3.5 1-[(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 1-[4-(3-methoxyphenyl)cyclohex-3-en-1-yl]-4-phenylpiperazine
-
 Homo sapiens
5.3.3.5 1-[4-(3-methoxyphenyl)cyclohex-3-en-1-yl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 1-[4-(3-methoxyphenyl)cyclohexyl]-4-phenylpiperazine
-
 Homo sapiens
5.3.3.5 1-[cis-4-(2-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 1-[cis-4-(3-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 1-[cis-4-(4-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 1-[trans-4-(2-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 1-[trans-4-(3-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 1-[trans-4-(4-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 3-[4-(4-naphthalen-1-ylpiperazin-1-yl)cyclohexyl]phenyl hydroperoxide
-
 Homo sapiens
5.3.3.5 4-[1-(2,6-dimethylphenyl)-3-cyclohexen-4-yl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 cis-4-(4-phenylcyclohexyl)-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 cis-4-[4-(2,6-difluorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 cis-4-[4-(2,6-dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 cis-4-[4-(2,6-dimethylyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 cis-4-[4-(2-chlorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 cis-4-[4-(2-methylphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine
-
 Homo sapiens
5.3.3.5 N-(2-phenylethyl)piperidine
-
 Homo sapiens
5.3.3.5 trans-4-(4-phenylcyclohexyl)-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 trans-4-[4-(2,6-difluorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 trans-4-[4-(2,6-dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 trans-4-[4-(2-chlorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 trans-4-[4-(2-methylphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.3.5 27000
-
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.3.3.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.3.5 PC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.3.5 5alpha-cholesta-8,24-dien-3beta-ol
-
 Homo sapiens 5alpha-cholesta-7,24-dien-3beta-ol
-
 ?
5.3.3.5 dihydrozymosterol
-
 Homo sapiens lathosterol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.3.5 3beta-hydroxysteroid DELTA8-DELTA7 isomerase
-
 Homo sapiens
5.3.3.5 Delta8-delta7 sterol isomerase
-
 Homo sapiens
5.3.3.5 EBP
-
 Homo sapiens
5.3.3.5 Emopamil binding protein
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.3.3.5 0.00000495
-
 cis-4-[4-(2,6-dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.000005
-
 cis-4-[4-(2-methylphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.000007
-
 trans-4-[4-(2,6-dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.00000721
-
 trans-4-[4-(2-chlorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.00000815
-
 1-[cis-4-(2-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 0.00000904
-
 trans-4-[4-(2-methylphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.0000135
-
 1-[trans-4-(2-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 0.0000146
-
 N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine
-
 Homo sapiens
5.3.3.5 0.0000162
-
 1-[trans-4-(3-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 0.0000164
-
 (+/-)-ifenprodil
-
 Homo sapiens
5.3.3.5 0.0000167
-
 3-[4-(4-naphthalen-1-ylpiperazin-1-yl)cyclohexyl]phenyl hydroperoxide
-
 Homo sapiens
5.3.3.5 0.0000168
-
 trans-4-(4-phenylcyclohexyl)-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.0000321
-
 1-[(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 0.0000328
-
 1-[cis-4-(4-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 0.0000331
-
 cis-4-[4-(2,6-dimethylyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.0000454
-
 1-[cis-4-(3-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 0.0000467
-
 4-[1-(2,6-dimethylphenyl)-3-cyclohexen-4-yl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.0000492
-
 cis-4-(4-phenylcyclohexyl)-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.0000716
-
 1-[trans-4-(4-methoxyphenyl)cyclohexyl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 0.0000851
-
 cis-4-[4-(2-chlorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.000106
-
 trans-4-[4-(2,6-difluorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.00014
-
 cis-4-[4-(2,6-difluorophenyl)cyclohexyl]-1-(2-pyridinyl)piperazine
-
 Homo sapiens
5.3.3.5 0.00046
-
 1-[4-(3-methoxyphenyl)cyclohex-3-en-1-yl]-4-phenylpiperazine
-
 Homo sapiens
5.3.3.5 0.000595
-
 N-(2-phenylethyl)piperidine
-
 Homo sapiens
5.3.3.5 0.00171
-
 1-[4-(3-methoxyphenyl)cyclohexyl]-4-phenylpiperazine
-
 Homo sapiens
5.3.3.5 0.00264
-
 1-[4-(3-methoxyphenyl)cyclohex-3-en-1-yl]-4-pyridin-2-ylpiperazine
-
 Homo sapiens
5.3.3.5 0.00766
-
 1,3-di-2-tolylguanidine
-
 Homo sapiens
5.3.3.5 0.01
-
 (+)-pentazocine Ki above 0.01 mM Homo sapiens