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Literature summary extracted from

  • Bello, A.M.; Poduch, E.; Liu, Y.; Wei, L.; Crandall, I.; Wang, X.; Dyanand, C.; Kain, K.C.; Pai, E.F.; Kotra, L.P.
    Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase (2008), J. Med. Chem., 51, 439-448.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.23
-
 Methanothermobacter thermautotrophicus
4.1.1.23
-
 Plasmodium falciparum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.23 the crystal structures of Plasmodium falciparum ODCase in complex with 6-I-UMP, 6-N3-UMP and 6-NH2-UMP are solved at resolutions of 1.95, 1.90 and 1.8 A, respectively Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.23 6-amino-uridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 6-aminouridine 5'-phosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 6-aza-uridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 6-azauridine 5'-phosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 6-azido-uridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 6-azidouridine 5'-phosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 6-cyano-uridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 6-cyanouridine 5'-phosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 6-methyl-uridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 6-methyluridine 5'-phosphate
-
 Methanothermobacter thermautotrophicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.23 Orotidine 5'-phosphate Methanothermobacter thermautotrophicus
-
 UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate Plasmodium falciparum
-
 UMP + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.23 Methanothermobacter thermautotrophicus
-
-
-
4.1.1.23 Plasmodium falciparum Q8IJH3
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.23
-
 Methanothermobacter thermautotrophicus
4.1.1.23
-
 Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.23 Orotidine 5'-phosphate
-
 Methanothermobacter thermautotrophicus UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Plasmodium falciparum UMP + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.23 ODCase
-
 Methanothermobacter thermautotrophicus
4.1.1.23 ODCase
-
 Plasmodium falciparum
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Methanothermobacter thermautotrophicus
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Plasmodium falciparum
4.1.1.23 Orotidine monophosphate decarboxylase
-
 Methanothermobacter thermautotrophicus
4.1.1.23 Orotidine monophosphate decarboxylase
-
 Plasmodium falciparum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.23 37
-
 activity assay Plasmodium falciparum
4.1.1.23 55
-
 activity assay Methanothermobacter thermautotrophicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.23 7.5
-
 activity assay Methanothermobacter thermautotrophicus
4.1.1.23 7.5
-
 activity assay Plasmodium falciparum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.23 0.00019
-
 6-azidouridine 5'-phosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 0.00084
-
 6-aminouridine 5'-phosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 0.0011
-
 6-aza-uridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 0.002
-
 6-azido-uridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 0.0021
-
 6-amino-uridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 0.0124
-
 6-azauridine 5'-phosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 0.026
-
 6-cyano-uridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 0.029
-
 6-cyanouridine 5'-phosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 0.0341
-
 6-methyl-uridine 5'-monophosphate
-
 Plasmodium falciparum
4.1.1.23 0.134
-
 6-methyluridine 5'-phosphate
-
 Methanothermobacter thermautotrophicus