Literature summary extracted from

Goodell, J.R.; Ougolkov, A.V.; Hiasa, H.; Kaur, H.; Remmel, R.; Billadeau, D.D.; Ferguson, D.M.
Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis (2008), J. Med. Chem., 51, 179-182.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.6.2.2	Aclarubicin	catalytic topo II inhibitor	Homo sapiens
5.6.2.2	amsacrine	topo II poison	Homo sapiens
5.6.2.2	doxorubicin	topo II poison	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.6.2.2	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
5.6.2.2	BxPC-3 cell	-	Homo sapiens	-
5.6.2.2	MiaPaCa-2 cell	-	Homo sapiens	-
5.6.2.2	pancreatic cancer cell	-	Homo sapiens	-
5.6.2.2	SU.86.86 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.6.2.2	supercoiled DNA + ATP + H2O	-	Homo sapiens	catenated DNA networks + ADP + phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
5.6.2.2	topo II	-	Homo sapiens
5.6.2.2	Topoisomerase II	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
5.6.2.2	ATP	-	Homo sapiens

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Release 2023.1 (January 2023)