EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.99 | (6aR,10aR)-3-(1,1-dimethylheptyl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol | - |
Rattus norvegicus | |
3.5.1.99 | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-morpholin-4-yl-1H-pyrazole-3-carboxamide | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.1.99 | 2.34 | - |
arachidonamide | pH 7.4, 37°C | Rattus norvegicus | |
3.5.1.99 | 2.78 | - |
anandamide | pH 7.4, 37°C | Rattus norvegicus | |
3.5.1.99 | 7.31 | - |
N-(o-hydroxyphenyl)arachidonamide | pH 7.4, 37°C | Rattus norvegicus | |
3.5.1.99 | 7.94 | - |
(S)-alpha-methanandamide | pH 7.4, 37°C | Rattus norvegicus | |
3.5.1.99 | 33 | - |
(R)-alpha-methanandamide | pH 7.4, 37°C | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.5.1.99 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.99 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.1.99 | brain | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.99 | (5Z,8Z,11Z,14Z)-N-(2-fluoroethyl)icosa-5,8,11,14-tetraenamide + H2O | hydrolysis rate is 1.3fold higher than the rate of anandamide hydrolysis | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (5Z,8Z,11Z,14Z)-N-(2-hydroxy-1,1-dimethylethyl)icosa-5,8,11,14-tetraenamide + H2O | hydrolyzed at 4.3% the rate of anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (5Z,8Z,11Z,14Z)-N-(2-methylpropyl)icosa-5,8,11,14-tetraenamide + H2O | hydrolyzed at 2% the rate of anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (5Z,8Z,11Z,14Z)-N-(3-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O | hydrolysis rate is 1.5fold higher than the rate of anandamide hydrolysis | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide + H2O | hydrolyzed at 16% the rate of anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (5Z,8Z,11Z,14Z)-N-tert-butylicosa-5,8,11,14-tetraenamide + H2O | hydrolyzed at 1.8% the rate of anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (5Z,8Z,11Z,14Z)-N-[(1S)-1-methylpropyl]icosa-5,8,11,14-tetraenamide + H2O | hydrolyzed at 6.3% the rate of anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (5Z,8Z,11Z,14Z)-N-[(2R)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O | hydrolysis rate is 1.2fold higher than the rate of anandamide hydrolysis | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (5Z,8Z,11Z,14Z)-N-[(2S)-2-hydroxypropyl]icosa-5,8,11,14-tetraenamide + H2O | hydrolyzed at 21% the rate of anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (9Z)-N-(2-hydroxyethyl)octadec-9-enamide + H2O | hydrolyzed at 61% the rate of anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dienamide + H2O | hydrolyzed at 75% the rate of anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (9Z,12Z)-N-[(1R)-2-hydroxy-1-methylethyl]octadeca-9,12-dienamide + H2O | hydrolyzed at 20.5% the rate of anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (R)-alpha-methanandamide + H2O | 2.4% of the activity with anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (R)-beta-methanandamide + H2O | 121% of the activity with anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (S)-alpha-methanandamide + H2O | 23% of the activity with anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | (S)-beta-methanandamide + H2O | 21% of the activity with anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | 1-arachidonoylglycerol + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.5.1.99 | 2-arachidonoylglycerol + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.5.1.99 | anandamide + H2O | - |
Rattus norvegicus | ethanolamine + arachidonic acid | - |
? | |
3.5.1.99 | arachidonamide + H2O | - |
Rattus norvegicus | arachidonic acid + NH3 | - |
? | |
3.5.1.99 | beta-arachidonoylglycerol + H2O | hydrolysis is 2.5fold higher than the rate of anandamide hydrolysis | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | additional information | N,N-bis(2-hydroxyethyl)arachidonamide is not hydrolyzed | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | N-(2-hydroxyethyl)octadecanamide + H2O | hydrolyzed at 15.0% the rate of anandamide | Rattus norvegicus | ? | - |
? | |
3.5.1.99 | N-(o-hydroxyphenyl)arachidonamide + H2O | - |
Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.1.99 | AAH | - |
Rattus norvegicus |
3.5.1.99 | anandamide amidohydrolase | - |
Rattus norvegicus |