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Literature summary extracted from

  • McIntyre, T.M.; Prescott, S.M.; Stafforini, D.M.
    The emerging roles of PAF acetylhydrolase (2009), J. Lipid Res., 50, S255-S259.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Mammalia
-
 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Mammalia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 brain expression of PAFAH2 mRNA Mammalia
-
3.1.1.47 brain robust expression of PLA2G7 mRNA Mammalia
-
3.1.1.47 kidney expression of PAFAH2 mRNA Mammalia
-
3.1.1.47 liver expression of PAFAH2 mRNA Mammalia
-
3.1.1.47 liver the type II liver isoform is found in several soft tissues Mammalia
-
3.1.1.47 macrophage
-
 Mammalia
-
3.1.1.47 placenta robust expression of PLA2G7 mRNA Mammalia
-
3.1.1.47 secretion
-
 Mammalia
-
3.1.1.47 testis expression of PAFAH2 mRNA Mammalia
-
3.1.1.47 white adipose tissue robust expression of PLA2G7 mRNA Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
-
 Mammalia 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 additional information group VII plasma and type II enzymes also hydrolyze unmodified sn-2 fatty acyl residues up to 5 or 6 carbon atoms long, but this length restriction is greatly relaxed when the omega-end of the sn-2 residue contains oxidized functions Mammalia ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 Ca2+-independent phospholipase A2
-
 Mammalia
3.1.1.47 group VII phospholipase A2
-
 Mammalia
3.1.1.47 group VIII phospholipase A2
-
 Mammalia
3.1.1.47 lipoprotein associated phospholipase A2
-
 Mammalia
3.1.1.47 LpPLA2
-
 Mammalia
3.1.1.47 PAF acetylhydrolase
-
 Mammalia
3.1.1.47 PAF-AH
-
 Mammalia
3.1.1.47 PAFAH2
-
 Mammalia
3.1.1.47 PLA2G7
-
 Mammalia
3.1.1.47 plasma PAF-AH
-
 Mammalia
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Mammalia