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Literature summary extracted from
- Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism (2008), J. Lipid Res., 49, 2493-2503.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.3.4 | gene LPIN2 is located on chromosome 18p11 | Homo sapiens |
| 3.1.3.4 | genes Lpin1, Lpin2, and Lpin3, expression analysis reveals distinct gene regulation in the hepatocytes | Mus musculus |
| 3.1.3.4 | genes Lpin1, Lpin2, and Lpin3, expression analysis reveals distinct gene regulation in the hepatocytes | Rattus norvegicus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.1.3.4 | additional information | lipin-1-deficient fld mice show that lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle, targeted expression of lipin-1 in adipose tissue of transgenic mice leads to obesity, overview | Mus musculus |
| 3.1.3.4 | additional information | mutations of lipin-1 cause recurrent acute myoglobinuria, lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.4 | N-ethylmaleimide | - |
Homo sapiens |  |
| 3.1.3.4 | N-ethylmaleimide | - |
Mus musculus | |
| 3.1.3.4 | N-ethylmaleimide | - |
Rattus norvegicus | |
| 3.1.3.4 | N-ethylmaleimide | - |
Saccharomyces cerevisiae | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.3.4 | cytosol | - |
Mus musculus | 5829 | - |
| 3.1.3.4 | cytosol | - |
Homo sapiens | 5829 | - |
| 3.1.3.4 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 3.1.3.4 | cytosol | - |
Saccharomyces cerevisiae | 5829 | - |
| 3.1.3.4 | endoplasmic reticulum | the enzyme binds to the cytosolic side of the membranes, overview | Mus musculus | 5783 | - |
| 3.1.3.4 | endoplasmic reticulum | the enzyme binds to the cytosolic side of the membranes, overview | Homo sapiens | 5783 | - |
| 3.1.3.4 | endoplasmic reticulum | the enzyme binds to the cytosolic side of the membranes, overview | Rattus norvegicus | 5783 | - |
| 3.1.3.4 | membrane | bound to microsomal and plasma membranes | Mus musculus | 16020 | - |
| 3.1.3.4 | membrane | bound to microsomal and plasma membranes | Homo sapiens | 16020 | - |
| 3.1.3.4 | membrane | bound to microsomal and plasma membranes | Rattus norvegicus | 16020 | - |
| 3.1.3.4 | nucleus | lipin-1 | Mus musculus | 5634 | - |
| 3.1.3.4 | nucleus | lipin-1 | Homo sapiens | 5634 | - |
| 3.1.3.4 | nucleus | lipin-1 | Rattus norvegicus | 5634 | - |
| 3.1.3.4 | nucleus | Pah1p | Saccharomyces cerevisiae | 5634 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.4 | Mg2+ | required | Mus musculus | |
| 3.1.3.4 | Mg2+ | required | Homo sapiens | |
| 3.1.3.4 | Mg2+ | required | Rattus norvegicus | |
| 3.1.3.4 | Mg2+ | required | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | Mus musculus | key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | Homo sapiens | key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | Rattus norvegicus | key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | Saccharomyces cerevisiae | key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Pah1p regulates nuclear membrane growth during cell cycle. Phosphorylation plays an important role in modulation of enzyme activity, overview | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | additional information | Homo sapiens | lipin-1 operates as a transcriptional coactivator in the nucleus together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism. Lipin-1 levels are reduced in adipocytes from obesive persons. Lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia, muations of lipin-1 cause recurrent acute myoglobinuria | ? | - |
? | |
| 3.1.3.4 | additional information | Saccharomyces cerevisiae | lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism | ? | - |
? | |
| 3.1.3.4 | additional information | Mus musculus | lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism | ? | - |
? | |
| 3.1.3.4 | additional information | Rattus norvegicus | lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.4 | Homo sapiens | - |
- |
- |
| 3.1.3.4 | Mus musculus | - |
- |
- |
| 3.1.3.4 | Rattus norvegicus | - |
- |
- |
| 3.1.3.4 | Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.1.3.4 | phosphoprotein | phosphorylation play an important role in modulation of enzyme activity, phosphorylation of lipin-1 influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine | Homo sapiens |
| 3.1.3.4 | phosphoprotein | phosphorylation plays an important role in modulation of enzyme activity, phosphorylation of lipin-1 and lipin-2 is associated with reduced PAP1 activity druing mitosis, phosphorylation of lipin-1, mainly at Ser106, influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine | Mus musculus |
| 3.1.3.4 | phosphoprotein | phosphorylation plays an important role in modulation of enzyme activity, phosphorylation of lipin-1 influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine | Rattus norvegicus |
| 3.1.3.4 | phosphoprotein | phosphorylation, e.g. by Nem1p, plays an important role in modulation of enzyme activity, overview | Saccharomyces cerevisiae |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.3.4 | adipose tissue | lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle | Mus musculus | - |
| 3.1.3.4 | adipose tissue | lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle | Homo sapiens | - |
| 3.1.3.4 | adipose tissue | lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle | Rattus norvegicus | - |
| 3.1.3.4 | liver | expression of both splicing variants of lipin-1 | Mus musculus | - |
| 3.1.3.4 | liver | expression of both splicing variants of lipin-1 | Rattus norvegicus | - |
| 3.1.3.4 | additional information | tissue-dependent regulation of PAP1, overview | Mus musculus | - |
| 3.1.3.4 | additional information | tissue-dependent regulation of PAP1, overview | Homo sapiens | - |
| 3.1.3.4 | additional information | tissue-dependent regulation of PAP1, overview | Rattus norvegicus | - |
| 3.1.3.4 | skeletal muscle | lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle | Mus musculus | - |
| 3.1.3.4 | skeletal muscle | lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle | Homo sapiens | - |
| 3.1.3.4 | skeletal muscle | lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | - |
Mus musculus | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | - |
Homo sapiens | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | - |
Rattus norvegicus | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | - |
Saccharomyces cerevisiae | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview | Mus musculus | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview | Homo sapiens | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview | Rattus norvegicus | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | a 3-sn-phosphatidate + H2O | key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Pah1p regulates nuclear membrane growth during cell cycle. Phosphorylation plays an important role in modulation of enzyme activity, overview | Saccharomyces cerevisiae | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
| 3.1.3.4 | additional information | lipin-1 operates as a transcriptional coactivator in the nucleus together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism. Lipin-1 levels are reduced in adipocytes from obesive persons. Lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia, muations of lipin-1 cause recurrent acute myoglobinuria | Homo sapiens | ? | - |
? | |
| 3.1.3.4 | additional information | lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism | Saccharomyces cerevisiae | ? | - |
? | |
| 3.1.3.4 | additional information | lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism | Mus musculus | ? | - |
? | |
| 3.1.3.4 | additional information | lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism | Rattus norvegicus | ? | - |
? | |
| 3.1.3.4 | additional information | PAP1 activity is conferred by the DxDxT motif of the C-Lip domain contained in all lipin family members | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.3.4 | More | PAP1 activity is conferred by the DxDxT motif of the C-Lip domain contained in all lipin family members | Saccharomyces cerevisiae |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.3.4 | lipin-1 | - |
Mus musculus |
| 3.1.3.4 | lipin-1 | - |
Homo sapiens |
| 3.1.3.4 | lipin-1 | - |
Rattus norvegicus |
| 3.1.3.4 | lipin-1 | - |
Saccharomyces cerevisiae |
| 3.1.3.4 | lipin-2 | - |
Mus musculus |
| 3.1.3.4 | lipin-2 | - |
Homo sapiens |
| 3.1.3.4 | lipin-2 | - |
Rattus norvegicus |
| 3.1.3.4 | lipin-2 | - |
Saccharomyces cerevisiae |
| 3.1.3.4 | lipin-3 | - |
Mus musculus |
| 3.1.3.4 | lipin-3 | - |
Homo sapiens |
| 3.1.3.4 | lipin-3 | - |
Rattus norvegicus |
| 3.1.3.4 | lipin-3 | - |
Saccharomyces cerevisiae |
| 3.1.3.4 | More | the enzyme belongs to the lipin family | Mus musculus |
| 3.1.3.4 | More | the enzyme belongs to the lipin family | Homo sapiens |
| 3.1.3.4 | More | the enzyme belongs to the lipin family | Rattus norvegicus |
| 3.1.3.4 | More | the enzyme belongs to the lipin family | Saccharomyces cerevisiae |
| 3.1.3.4 | Pah1p | - |
Saccharomyces cerevisiae |
| 3.1.3.4 | PAP-1 | - |
Homo sapiens |
| 3.1.3.4 | PAP1 | - |
Mus musculus |
| 3.1.3.4 | PAP1 | - |
Rattus norvegicus |
| 3.1.3.4 | PAP1 | - |
Saccharomyces cerevisiae |
| 3.1.3.4 | phosphatidate phosphatase-1 | - |
Mus musculus |
| 3.1.3.4 | phosphatidate phosphatase-1 | - |
Homo sapiens |
| 3.1.3.4 | phosphatidate phosphatase-1 | - |
Rattus norvegicus |
| 3.1.3.4 | phosphatidate phosphatase-1 | - |
Saccharomyces cerevisiae |
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