BRENDA - Enzyme Database

Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism

Reue, K.; Brindley, D.N.; J. Lipid Res. 49, 2493-2503 (2008)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
3.1.3.4
gene LPIN2 is located on chromosome 18p11
Homo sapiens
3.1.3.4
genes Lpin1, Lpin2, and Lpin3, expression analysis reveals distinct gene regulation in the hepatocytes
Mus musculus
3.1.3.4
genes Lpin1, Lpin2, and Lpin3, expression analysis reveals distinct gene regulation in the hepatocytes
Rattus norvegicus
Engineering
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
additional information
mutations of lipin-1 cause recurrent acute myoglobinuria, lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia
Homo sapiens
3.1.3.4
additional information
lipin-1-deficient fld mice show that lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle, targeted expression of lipin-1 in adipose tissue of transgenic mice leads to obesity, overview
Mus musculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
N-ethylmaleimide
-
Homo sapiens
3.1.3.4
N-ethylmaleimide
-
Mus musculus
3.1.3.4
N-ethylmaleimide
-
Rattus norvegicus
3.1.3.4
N-ethylmaleimide
-
Saccharomyces cerevisiae
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
cytosol
-
Homo sapiens
5829
-
3.1.3.4
cytosol
-
Rattus norvegicus
5829
-
3.1.3.4
cytosol
-
Mus musculus
5829
-
3.1.3.4
cytosol
-
Saccharomyces cerevisiae
5829
-
3.1.3.4
endoplasmic reticulum
the enzyme binds to the cytosolic side of the membranes, overview
Homo sapiens
5783
-
3.1.3.4
endoplasmic reticulum
the enzyme binds to the cytosolic side of the membranes, overview
Mus musculus
5783
-
3.1.3.4
endoplasmic reticulum
the enzyme binds to the cytosolic side of the membranes, overview
Rattus norvegicus
5783
-
3.1.3.4
membrane
bound to microsomal and plasma membranes
Homo sapiens
16020
-
3.1.3.4
membrane
bound to microsomal and plasma membranes
Mus musculus
16020
-
3.1.3.4
membrane
bound to microsomal and plasma membranes
Rattus norvegicus
16020
-
3.1.3.4
nucleus
lipin-1
Homo sapiens
5634
-
3.1.3.4
nucleus
lipin-1
Mus musculus
5634
-
3.1.3.4
nucleus
lipin-1
Rattus norvegicus
5634
-
3.1.3.4
nucleus
Pah1p
Saccharomyces cerevisiae
5634
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.4
Mg2+
required
Homo sapiens
3.1.3.4
Mg2+
required
Mus musculus
3.1.3.4
Mg2+
required
Rattus norvegicus
3.1.3.4
Mg2+
required
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
a 3-sn-phosphatidate + H2O
Mus musculus
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
Homo sapiens
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
Rattus norvegicus
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
Saccharomyces cerevisiae
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Pah1p regulates nuclear membrane growth during cell cycle. Phosphorylation plays an important role in modulation of enzyme activity, overview
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
3.1.3.4
additional information
Homo sapiens
lipin-1 operates as a transcriptional coactivator in the nucleus together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism. Lipin-1 levels are reduced in adipocytes from obesive persons. Lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia, muations of lipin-1 cause recurrent acute myoglobinuria
?
-
-
-
3.1.3.4
additional information
Saccharomyces cerevisiae
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism
?
-
-
-
3.1.3.4
additional information
Mus musculus
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism
?
-
-
-
3.1.3.4
additional information
Rattus norvegicus
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Homo sapiens
-
-
-
3.1.3.4
Mus musculus
-
-
-
3.1.3.4
Rattus norvegicus
-
-
-
3.1.3.4
Saccharomyces cerevisiae
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
3.1.3.4
phosphoprotein
phosphorylation play an important role in modulation of enzyme activity, phosphorylation of lipin-1 influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine
Homo sapiens
3.1.3.4
phosphoprotein
phosphorylation plays an important role in modulation of enzyme activity, phosphorylation of lipin-1 and lipin-2 is associated with reduced PAP1 activity druing mitosis, phosphorylation of lipin-1, mainly at Ser106, influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine
Mus musculus
3.1.3.4
phosphoprotein
phosphorylation plays an important role in modulation of enzyme activity, phosphorylation of lipin-1 influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine
Rattus norvegicus
3.1.3.4
phosphoprotein
phosphorylation, e.g. by Nem1p, plays an important role in modulation of enzyme activity, overview
Saccharomyces cerevisiae
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
adipose tissue
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Homo sapiens
-
3.1.3.4
adipose tissue
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Mus musculus
-
3.1.3.4
adipose tissue
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Rattus norvegicus
-
3.1.3.4
liver
expression of both splicing variants of lipin-1
Mus musculus
-
3.1.3.4
liver
expression of both splicing variants of lipin-1
Rattus norvegicus
-
3.1.3.4
additional information
tissue-dependent regulation of PAP1, overview
Homo sapiens
-
3.1.3.4
additional information
tissue-dependent regulation of PAP1, overview
Mus musculus
-
3.1.3.4
additional information
tissue-dependent regulation of PAP1, overview
Rattus norvegicus
-
3.1.3.4
skeletal muscle
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Homo sapiens
-
3.1.3.4
skeletal muscle
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Mus musculus
-
3.1.3.4
skeletal muscle
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693521
Mus musculus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693521
Homo sapiens
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693521
Rattus norvegicus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693521
Saccharomyces cerevisiae
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
693521
Mus musculus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
693521
Homo sapiens
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
693521
Rattus norvegicus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Pah1p regulates nuclear membrane growth during cell cycle. Phosphorylation plays an important role in modulation of enzyme activity, overview
693521
Saccharomyces cerevisiae
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
additional information
lipin-1 operates as a transcriptional coactivator in the nucleus together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism. Lipin-1 levels are reduced in adipocytes from obesive persons. Lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia, muations of lipin-1 cause recurrent acute myoglobinuria
693521
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism
693521
Saccharomyces cerevisiae
?
-
-
-
-
3.1.3.4
additional information
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism
693521
Mus musculus
?
-
-
-
-
3.1.3.4
additional information
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism
693521
Rattus norvegicus
?
-
-
-
-
3.1.3.4
additional information
PAP1 activity is conferred by the DxDxT motif of the C-Lip domain contained in all lipin family members
693521
Saccharomyces cerevisiae
?
-
-
-
-
Subunits
EC Number
Subunits
Commentary
Organism
3.1.3.4
More
PAP1 activity is conferred by the DxDxT motif of the C-Lip domain contained in all lipin family members
Saccharomyces cerevisiae
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.3.4
gene LPIN2 is located on chromosome 18p11
Homo sapiens
3.1.3.4
genes Lpin1, Lpin2, and Lpin3, expression analysis reveals distinct gene regulation in the hepatocytes
Mus musculus
3.1.3.4
genes Lpin1, Lpin2, and Lpin3, expression analysis reveals distinct gene regulation in the hepatocytes
Rattus norvegicus
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
additional information
mutations of lipin-1 cause recurrent acute myoglobinuria, lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia
Homo sapiens
3.1.3.4
additional information
lipin-1-deficient fld mice show that lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle, targeted expression of lipin-1 in adipose tissue of transgenic mice leads to obesity, overview
Mus musculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
N-ethylmaleimide
-
Homo sapiens
3.1.3.4
N-ethylmaleimide
-
Mus musculus
3.1.3.4
N-ethylmaleimide
-
Rattus norvegicus
3.1.3.4
N-ethylmaleimide
-
Saccharomyces cerevisiae
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
cytosol
-
Homo sapiens
5829
-
3.1.3.4
cytosol
-
Rattus norvegicus
5829
-
3.1.3.4
cytosol
-
Mus musculus
5829
-
3.1.3.4
cytosol
-
Saccharomyces cerevisiae
5829
-
3.1.3.4
endoplasmic reticulum
the enzyme binds to the cytosolic side of the membranes, overview
Homo sapiens
5783
-
3.1.3.4
endoplasmic reticulum
the enzyme binds to the cytosolic side of the membranes, overview
Mus musculus
5783
-
3.1.3.4
endoplasmic reticulum
the enzyme binds to the cytosolic side of the membranes, overview
Rattus norvegicus
5783
-
3.1.3.4
membrane
bound to microsomal and plasma membranes
Homo sapiens
16020
-
3.1.3.4
membrane
bound to microsomal and plasma membranes
Mus musculus
16020
-
3.1.3.4
membrane
bound to microsomal and plasma membranes
Rattus norvegicus
16020
-
3.1.3.4
nucleus
lipin-1
Homo sapiens
5634
-
3.1.3.4
nucleus
lipin-1
Mus musculus
5634
-
3.1.3.4
nucleus
lipin-1
Rattus norvegicus
5634
-
3.1.3.4
nucleus
Pah1p
Saccharomyces cerevisiae
5634
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.4
Mg2+
required
Homo sapiens
3.1.3.4
Mg2+
required
Mus musculus
3.1.3.4
Mg2+
required
Rattus norvegicus
3.1.3.4
Mg2+
required
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
a 3-sn-phosphatidate + H2O
Mus musculus
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
Homo sapiens
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
Rattus norvegicus
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
Saccharomyces cerevisiae
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Pah1p regulates nuclear membrane growth during cell cycle. Phosphorylation plays an important role in modulation of enzyme activity, overview
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
3.1.3.4
additional information
Homo sapiens
lipin-1 operates as a transcriptional coactivator in the nucleus together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism. Lipin-1 levels are reduced in adipocytes from obesive persons. Lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia, muations of lipin-1 cause recurrent acute myoglobinuria
?
-
-
-
3.1.3.4
additional information
Saccharomyces cerevisiae
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism
?
-
-
-
3.1.3.4
additional information
Mus musculus
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism
?
-
-
-
3.1.3.4
additional information
Rattus norvegicus
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism
?
-
-
-
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
3.1.3.4
phosphoprotein
phosphorylation play an important role in modulation of enzyme activity, phosphorylation of lipin-1 influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine
Homo sapiens
3.1.3.4
phosphoprotein
phosphorylation plays an important role in modulation of enzyme activity, phosphorylation of lipin-1 and lipin-2 is associated with reduced PAP1 activity druing mitosis, phosphorylation of lipin-1, mainly at Ser106, influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine
Mus musculus
3.1.3.4
phosphoprotein
phosphorylation plays an important role in modulation of enzyme activity, phosphorylation of lipin-1 influences its subcellular localization, dephosphorylation of lipin-1 in response to oleic acid and epinephrine
Rattus norvegicus
3.1.3.4
phosphoprotein
phosphorylation, e.g. by Nem1p, plays an important role in modulation of enzyme activity, overview
Saccharomyces cerevisiae
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
adipose tissue
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Homo sapiens
-
3.1.3.4
adipose tissue
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Mus musculus
-
3.1.3.4
adipose tissue
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Rattus norvegicus
-
3.1.3.4
liver
expression of both splicing variants of lipin-1
Mus musculus
-
3.1.3.4
liver
expression of both splicing variants of lipin-1
Rattus norvegicus
-
3.1.3.4
additional information
tissue-dependent regulation of PAP1, overview
Homo sapiens
-
3.1.3.4
additional information
tissue-dependent regulation of PAP1, overview
Mus musculus
-
3.1.3.4
additional information
tissue-dependent regulation of PAP1, overview
Rattus norvegicus
-
3.1.3.4
skeletal muscle
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Homo sapiens
-
3.1.3.4
skeletal muscle
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Mus musculus
-
3.1.3.4
skeletal muscle
lipin-1 accounts for all of the PAP1 activity in adipose tissue and skeletal muscle
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693521
Mus musculus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693521
Homo sapiens
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693521
Rattus norvegicus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693521
Saccharomyces cerevisiae
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
693521
Mus musculus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
693521
Homo sapiens
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview
693521
Rattus norvegicus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Pah1p regulates nuclear membrane growth during cell cycle. Phosphorylation plays an important role in modulation of enzyme activity, overview
693521
Saccharomyces cerevisiae
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
additional information
lipin-1 operates as a transcriptional coactivator in the nucleus together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism. Lipin-1 levels are reduced in adipocytes from obesive persons. Lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia, muations of lipin-1 cause recurrent acute myoglobinuria
693521
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism
693521
Saccharomyces cerevisiae
?
-
-
-
-
3.1.3.4
additional information
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism
693521
Mus musculus
?
-
-
-
-
3.1.3.4
additional information
lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism
693521
Rattus norvegicus
?
-
-
-
-
3.1.3.4
additional information
PAP1 activity is conferred by the DxDxT motif of the C-Lip domain contained in all lipin family members
693521
Saccharomyces cerevisiae
?
-
-
-
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
3.1.3.4
More
PAP1 activity is conferred by the DxDxT motif of the C-Lip domain contained in all lipin family members
Saccharomyces cerevisiae