Literature summary extracted from

Leite-de-Moraes, M.C.; Diem, S.; Michel, M.L.; Ohtsu, H.; Thurmond, R.L.; Schneider, E.; Dy, M.
Cutting edge: Histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-gamma production by invariant NKT cells (2009), J. Immunol., 182, 1233-1236.

Application

EC Number	Application	Comment	Organism
4.1.1.22	medicine	histidine decarboxylase-deficient mice present a numerical and functional deficit in invariant NK T cells as evidenced by a drastic decrease of IL-4 and IFN-gamma production	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.1.22	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.1.1.22	natural killer cell	-	Mus musculus	-
4.1.1.22	T-lymphocyte	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.1.1.22	L-histidine	-	Mus musculus	histamine + CO2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
4.1.1.22	HDC	-	Mus musculus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
4.1.1.22	pyridoxal 5'-phosphate	-	Mus musculus

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Release 2023.1 (January 2023)