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Literature summary extracted from

  • Graf, C.; Zemann, B.; Rovina, P.; Urtz, N.; Schanzer, A.; Reuschel, R.; Mechtcheriakova, D.; Mueller, M.; Fischer, E.; Reichel, C.; Huber, S.; Dawson, J.; Meingassner, J.G.; Billich, A.; Niwa, S.; Badegruber, R.; Van Veldhoven, P.P.; Kinzel, B.; Baumruker, T.; Bornancin, F.
    Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice (2008), J. Immunol., 180, 3457-3466.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.138 medicine ceramide kinase is important for neutrophil homeostasis, ceramide kinase is important for the defense against Streptococcus pneumoniae infections Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.138 Golgi apparatus
-
 Mus musculus 5794
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.138 Ca2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ceramide + ATP Mus musculus ceramide kinase is not the only source of ceramide 1-phosphate, ceramide kinase is important for neutrophil homeostasis, ceramide kinase is important for the defense against Streptococcus pneumoniae infections ceramide 1-phosphate + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 bone marrow
-
 Mus musculus
-
2.7.1.138 leukocyte
-
 Mus musculus
-
2.7.1.138 macrophage bone marrow-derived macrophage, BMDM Mus musculus
-
2.7.1.138 mast cell bone marrow-derived mast cell Mus musculus
-
2.7.1.138 neutrophil
-
 Mus musculus
-
2.7.1.138 peritoneal macrophage
-
 Mus musculus
-
2.7.1.138 spleen
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.138 0.000000004
-
 liver of wild-type mice Mus musculus
2.7.1.138 0.000000028
-
 kidney of wild-type mice Mus musculus
2.7.1.138 0.000000038
-
 pancreas of wild-type mice Mus musculus
2.7.1.138 0.000001191
-
 testis of wild-type mice Mus musculus
2.7.1.138 0.00000141
-
 cerebellum of wild-type mice Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ceramide + ATP
-
 Mus musculus ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP ceramide kinase is not the only source of ceramide 1-phosphate, ceramide kinase is important for neutrophil homeostasis, ceramide kinase is important for the defense against Streptococcus pneumoniae infections Mus musculus ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl-D-erythrosphingosine + ATP
-
 Mus musculus N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl-D-erythrosphingosine 1-phosphate + ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
-
 Mus musculus