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Literature summary extracted from

  • Beghdadi, W.; Porcherie, A.; Schneider, B.S.; Dubayle, D.; Peronet, R.; Huerre, M.; Watanabe, T.; Ohtsu, H.; Louis, J.; Mecheri, S.
    Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease (2008), J. Exp. Med., 205, 395-408.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.1.1.22 medicine histamine-mediated signaling contributes to malaria pathogenesis, histidine decarboxylase-deficient mice are highly resistant to severe malaria and display resistance to Plasmodium berghei strains ANKA and NK65 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine
-
 Mus musculus histamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate
-
 Mus musculus