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Literature summary extracted from

  • Pasca, S.P.; Dronca, E.; Nemes, B.; Kaucsar, T.; Endreffy, E.; Iftene, F.; Benga, I.; Cornean, R.; Dronca, M.
    Paraoxonase 1 activities and polymorphisms in autism spectrum disorders (2010), J. Cell. Mol. Med., 14, 600-607.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.1.2 medicine both PON1 bioavailability and catalytic activity are decreased in children with autism spectrum disorders Homo sapiens
3.1.8.1 medicine both PON1 bioavailability and catalytic activity are decreased in children with autism spectrum disorders Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens
-
-
-
3.1.8.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.2 blood plasma
-
 Homo sapiens
-
3.1.8.1 blood plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.2 85.05
-
 using phenyl acetate as substrate (arylesterase activity of PON1), at 25°C Homo sapiens
3.1.8.1 0.611
-
 using paraoxin as substrate (paraoxonase activity of PON1), at 25°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 additional information PON1 catalyses the hydrolysis of arylesters, toxic organophosphate compounds, carbamates and lactones, shows higher arylesterase than paraoxonase activity Homo sapiens ?
-
 ?
3.1.1.2 phenyl acetate + H2O
-
 Homo sapiens phenol + acetate
-
 ?
3.1.8.1 paraoxon + H2O
-
 Homo sapiens diethylphosphate + 4-nitrophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.8.1 HDL-associated esterase/lactonase paraoxonase 1
-
 Homo sapiens
3.1.8.1 high-density lipoprotein-associated esterase/lactonase
-
 Homo sapiens
3.1.8.1 paraoxonase
-
 Homo sapiens
3.1.8.1 paraoxonase 1
-
 Homo sapiens
3.1.8.1 PO.ase
-
 Homo sapiens
3.1.8.1 PON1 catalyses the hydrolysis of arylesters, toxic organophosphate compounds, carbamates and lactones, shows higher arylesterase than paraoxonase activity Homo sapiens