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Literature summary extracted from

  • Berletch, J.B.; Liu, C.; Love, W.K.; Andrews, L.G.; Katiyar, S.K.; Tollefsbol, T.O.
    Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG (2008), J. Cell. Biochem., 103, 509-519.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.49 (-)-epigallocatechin-3-gallate exposure to (-)-epigallocatechin-3-gallate reduces cellular proliferation and induced apoptosis in both MCF-7 and HL60 cells in vitro, although TERT mRNA expression is decreased only in MCF-7 cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.49 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.49 HL-60 cell
-
 Homo sapiens
-
2.7.7.49 MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.49 deoxynucleoside triphosphate + DNAn
-
 Homo sapiens diphosphate + DNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.49 telomerase reverse transcriptase
-
 Homo sapiens
2.7.7.49 TERT
-
 Homo sapiens