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Literature summary extracted from

  • Gropler, M.C.; Harris, T.E.; Hall, A.M.; Wolins, N.E.; Gross, R.W.; Han, X.; Chen, Z.; Finck, B.N.
    Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice (2009), J. Biol. Chem., 284, 6763-6772.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.4 additional information hepatic lipin 2 protein content is markedly increased by lipin 1 deficiency, food deprivation, and obesity, often independent of changes in steady-state mRNA levels. Fasting induces expression of Lpin1 and Lpin2 in wild-type and PGC-1alpha-deficient mice Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 expression analysis of lipin-1 and lipin-2, recombinant expression of lipin-2 in Hep-G2 cells using an adenoviral vector Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.4 additional information livers of fld mice lacking lipin 1 exhibit normal PAP-1 activity and a 20fold increase in triglyceride levels, while the hepatic content of phosphatidate is markedly diminished in fld mice. Other phospholipids derived from phosphatidate, phosphatidylglycerol and cardiolipin, are also depleted. Hepatic lipin 2 protein content is markedly increased by lipin 1 deficiency via a posttranscriptional mechanism Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 cytosol lipin-1 and lipin-2 are soluble proteins that can also be localized to the nucleus or associate with endoplasmic reticulum membranes Mus musculus 5829
-
3.1.3.4 endoplasmic reticulum membrane lipin-1 and lipin-2 are soluble proteins that can also be localized to the nucleus or associate with endoplasmic reticulum membranes Mus musculus 5789
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 a 3-sn-phosphatidate + H2O Mus musculus lipin 1 is a bifunctional intracellular protein that regulates fatty acid metabolism in the nucleus via interactions with DNA-bound transcription factors and at the endoplasmic reticulum as a phosphatidic acid phosphohydrolase enzyme to catalyze the penultimate step in triglyceride synthesis. Lipin 2 plays an important role as a hepatic PAP-1 enzyme a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 additional information Mus musculus lipin 2 is dynamically regulated in liver but is not a target gene of PGC-1alpha ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Mus musculus
-
 genes Lpin1 and Lpin2
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.4 phosphoprotein serine 106 residue of lipin-1 and lipin-2 is a major site of phosphorylation Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 liver lipin-1 and high activity of lipin-2 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.4 additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 a 3-sn-phosphatidate + H2O
-
 Mus musculus a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 a 3-sn-phosphatidate + H2O lipin 1 is a bifunctional intracellular protein that regulates fatty acid metabolism in the nucleus via interactions with DNA-bound transcription factors and at the endoplasmic reticulum as a phosphatidic acid phosphohydrolase enzyme to catalyze the penultimate step in triglyceride synthesis. Lipin 2 plays an important role as a hepatic PAP-1 enzyme Mus musculus a 1,2-diacyl-sn-glycerol + phosphate
-
 ?
3.1.3.4 additional information lipin 2 is dynamically regulated in liver but is not a target gene of PGC-1alpha Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipin-1
-
 Mus musculus
3.1.3.4 lipin-2
-
 Mus musculus
3.1.3.4 More the enzyme is a member of the lipin family Mus musculus
3.1.3.4 PAP-1
-
 Mus musculus
3.1.3.4 phosphatidate phosphohydrolase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.4 30
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.4 7
-
 assay at Mus musculus