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Literature summary extracted from

  • Hochbaum, D.; Hong, K.; Barila, G.; Ribeiro-Neto, F.; Altschuler, D.L.
    Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis (2008), J. Biol. Chem., 283, 4464-4468.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 forskolin
-
 Rattus norvegicus
2.7.11.11 N6-benzoyladenosine-3',5'-cyclic monophosphate PKA-specific cAMP analog Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 H-89
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 additional information Rattus norvegicus exchange protein activated by cAMP acts synergistically with PKA in cAMP-mediated mitogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 PCCL-3 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + cAMP-response element-binding protein
-
 Rattus norvegicus ADP + phosphorylated cAMP-response element-binding protein
-
 ?
2.7.11.11 additional information exchange protein activated by cAMP acts synergistically with PKA in cAMP-mediated mitogenesis Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Rattus norvegicus
2.7.11.11 cAMP dependent Rattus norvegicus