Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Perez-Garcia, M.J.; Gou-Fabregas, M.; de Pablo, Y.; Llovera, M.; Comella, J.X.; Soler, R.M.
    Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV (2008), J. Biol. Chem., 283, 4133-4144.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 expressed in HEK-293T cells Gallus gallus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 K60E mutant is kinase dead Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 cytosol
-
 Gallus gallus 5829
-
2.7.11.17 nucleus mainly localized in the nucleus Gallus gallus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on, 2 mM CaCl2 plus 0.001 mM calmodulin induce 69.2% activation of CaMKIV activity Gallus gallus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.17 40000
-
 SDS-PAGE Gallus gallus
2.7.11.17 41300
-
 estimated from amino acid sequence Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.17 anti-FLAG-Sepharose chromatography Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 motoneuron
-
 Gallus gallus
-
2.7.11.17 spinal cord
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + cAMP response element binding protein
-
 Gallus gallus ADP + phosphorylated cAMP response element binding protein
-
 ?
2.7.11.17 ATP + phosphatidylinositol 3-kinase
-
 Gallus gallus ADP + phosphorylated phosphatidylinositol 3-kinase
-
 ?
2.7.11.17 ATP + protein kinase B
-
 Gallus gallus ADP + phosphorylated protein kinase B
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 Ca2+/CaM-dependent protein kinase
-
 Gallus gallus
2.7.11.17 calmodulin kinase IV
-
 Gallus gallus
2.7.11.17 CaMKIV
-
 Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Gallus gallus
2.7.11.17 Calmodulin dependent on, 2 mM CaCl2 plus 0.001 mM calmodulin induce 69.2% activation of CaMKIV activity Gallus gallus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.11.17 Gallus gallus estimated from amino acid sequence
-
 8.28