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Literature summary extracted from

  • Veiga-da-Cunha, M.; Vleugels, W.; Maliekal, P.; Matthijs, G.; Van Schaftingen, E.
    Mammalian phosphomannomutase PMM1 is the brain IMP-sensitive glucose-1,6-bisphosphatase (2008), J. Biol. Chem., 283, 33988-33993.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.2.8 expressed in Escherichia coli BL21(DE3) cells and HEK-293T cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.2.8 IMP IMP stimulates by more than 100fold the intrinsic glucose-1,6-bisphosphatase activity of recombinant PMM1 while inhibiting its phosphoglucomutase activity Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
5.4.2.8 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.2.8 Ni-NTA column chromatography Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.2.8 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.2.8 alpha-D-glucose 1,6-bisphosphate
-
 Mus musculus ?
-
 ?
5.4.2.8 alpha-D-mannose 1-phosphate
-
 Mus musculus alpha-D-mannose 6-phosphate
-
 ?
5.4.2.8 additional information PMM1 is less specific: it has nearly equal phosphomannomutase and phosphoglucomutase activities as well as a modest glucose-1,6-bisphosphatase activity corresponding to about 3% of its phosphomannomutase activity Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.4.2.8 IMP-sensitive glucose-1,6-bisphosphatase
-
 Mus musculus
5.4.2.8 phosphomannomutase 1
-
 Mus musculus
5.4.2.8 PMM1 multifunctional enzyme Mus musculus