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Literature summary extracted from

  • Okazaki, H.; Igarashi, M.; Nishi, M.; Sekiya, M.; Tajima, M.; Takase, S.; Takanashi, M.; Ohta, K.; Tamura, Y.; Okazaki, S.; Yahagi, N.; Ohashi, K.; Amemiya-Kudo, M.; Nakagawa, Y.; Nagai, R.; Kadowaki, T.; Osuga, J.; Ishibashi, S.
    Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages (2008), J. Biol. Chem., 283, 33357-33364.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.13 NaCl the nCEH activity in the whole cell lysates from NCEH-transfected cells is slightly stimulated by low concentrations of NaCl (6.5% at 0.05 M) Mus musculus
3.1.1.13 NaCl the nCEH activity in the whole cell lysates from NCEH-transfected cells is slightly stimulated by low concentrations of NaCl (6.5% at 0.05M) Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.13 expressed in HEK-293 cells Homo sapiens
3.1.1.13 expressed in RAW264.7 cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 NaCl 31% inhibition at 1 mM Homo sapiens
3.1.1.13 NaCl 31% inhibition at 1 mM Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.13 microsome
-
Homo sapiens
-
-
3.1.1.13 microsome
-
Mus musculus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Homo sapiens
-
-
-
3.1.1.13 Mus musculus Q8BLF1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 kidney expressed at high levels in kidney Homo sapiens
-
3.1.1.13 kidney expressed at high levels in kidney Mus musculus
-
3.1.1.13 macrophage expressed at high levels in macrophages Homo sapiens
-
3.1.1.13 macrophage expressed at high levels in peritoneal macrophages Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl oleate + H2O
-
Homo sapiens cholesterol + oleate
-
?
3.1.1.13 cholesteryl oleate + H2O
-
Mus musculus cholesterol + oleate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 CE hydrolase
-
Homo sapiens
3.1.1.13 CE hydrolase
-
Mus musculus
3.1.1.13 KIAA1363
-
Homo sapiens
3.1.1.13 KIAA1363
-
Mus musculus
3.1.1.13 NCEH recombinant enzyme Homo sapiens
3.1.1.13 NCEH recombinant enzyme Mus musculus
3.1.1.13 NCEH native enzyme Homo sapiens
3.1.1.13 NCEH native enzyme Mus musculus
3.1.1.13 neutral cholesterol ester hydrolase
-
Homo sapiens
3.1.1.13 neutral cholesterol ester hydrolase
-
Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.13 7.2
-
-
Homo sapiens
3.1.1.13 7.2
-
-
Mus musculus