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Literature summary extracted from

  • Gin, P.; Yin, L.; Davies, B.S.; Weinstein, M.M.; Ryan, R.O.; Bensadoun, A.; Fong, L.G.; Young, S.G.; Beigneux, A.P.
    The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons (2008), J. Biol. Chem., 283, 29554-29562.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.34 heparin heparin treatment results in an 11.75fold increase of LPL in the cell culture medium Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.34 K430A/R432A/K434A/K440A/K441A the mutant LPL has little or no ability to bind to GPIHBP1 on the surface of cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.34 additional information polyaspartate, polyglutamate and a a rabbit antiserum against the acidic domain of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) block the binding of LPL to GPIHBP1 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.34 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.34 chylomicron + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.34 triolein + H2O
-
 Homo sapiens oleate + diolein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.34 LPL
-
 Homo sapiens