BRENDA - Enzyme Database

Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2

Grimsey, N.; Han, G.S.; OHara, L.; Rochford, J.J.; Carman, G.M.; Siniossoglou, S.; J. Biol. Chem. 283, 29166-29174 (2008)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
3.1.3.4
expression of lipin-1 in HeLa M cells
Homo sapiens
3.1.3.4
expression of lipin-2 in HeLa M cells
Mus musculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
additional information
mitotic phosphorylation of lipin 1 inhibits its phosphatidic acid phosphatase activity
Homo sapiens
3.1.3.4
additional information
mitotic phosphorylation of lipin 2 inhibits its phosphatidic acid phosphatase activity
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
a 3-sn-phosphatidate + H2O
Homo sapiens
lipin-1 is negatively regulated by phosphorylation during mitosis
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
Mus musculus
lipin-2 is negatively regulated by phosphorylation during mitosis
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Homo sapiens
Q14693
-
-
3.1.3.4
Mus musculus
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
3.1.3.4
phosphoprotein
mitotic phosphorylation of lipin 1 inhibits its phosphatidic acid phosphatase activity
Homo sapiens
3.1.3.4
phosphoprotein
mitotic phosphorylation of lipin 2 inhibits its phosphatidic acid phosphatase activity
Mus musculus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
adipose tissue
PAP1 activity increases during adipogenesis
Homo sapiens
-
3.1.3.4
adipose tissue
PAP1 activity increases during adipogenesis
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693153
Mus musculus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693153
Homo sapiens
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
lipin-1 is negatively regulated by phosphorylation during mitosis
693153
Homo sapiens
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
lipin-2 is negatively regulated by phosphorylation during mitosis
693153
Mus musculus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
Temperature Optimum [C]
EC Number
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
3.1.3.4
30
-
assay at
Homo sapiens
3.1.3.4
30
-
assay at
Mus musculus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.1.3.4
7.4
-
assay at
Homo sapiens
3.1.3.4
7.4
-
assay at
Mus musculus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.3.4
expression of lipin-1 in HeLa M cells
Homo sapiens
3.1.3.4
expression of lipin-2 in HeLa M cells
Mus musculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.3.4
additional information
mitotic phosphorylation of lipin 1 inhibits its phosphatidic acid phosphatase activity
Homo sapiens
3.1.3.4
additional information
mitotic phosphorylation of lipin 2 inhibits its phosphatidic acid phosphatase activity
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
a 3-sn-phosphatidate + H2O
Homo sapiens
lipin-1 is negatively regulated by phosphorylation during mitosis
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
Mus musculus
lipin-2 is negatively regulated by phosphorylation during mitosis
a 1,2-diacyl-sn-glycerol + phosphate
-
-
?
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
3.1.3.4
phosphoprotein
mitotic phosphorylation of lipin 1 inhibits its phosphatidic acid phosphatase activity
Homo sapiens
3.1.3.4
phosphoprotein
mitotic phosphorylation of lipin 2 inhibits its phosphatidic acid phosphatase activity
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
adipose tissue
PAP1 activity increases during adipogenesis
Homo sapiens
-
3.1.3.4
adipose tissue
PAP1 activity increases during adipogenesis
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693153
Mus musculus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
-
693153
Homo sapiens
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
lipin-1 is negatively regulated by phosphorylation during mitosis
693153
Homo sapiens
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
3.1.3.4
a 3-sn-phosphatidate + H2O
lipin-2 is negatively regulated by phosphorylation during mitosis
693153
Mus musculus
a 1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
Temperature Optimum [C] (protein specific)
EC Number
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
3.1.3.4
30
-
assay at
Homo sapiens
3.1.3.4
30
-
assay at
Mus musculus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.1.3.4
7.4
-
assay at
Homo sapiens
3.1.3.4
7.4
-
assay at
Mus musculus