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Literature summary extracted from

  • Manni, S.; Mauban, J.H.; Ward, C.W.; Bond, M.
    Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells (2008), J. Biol. Chem., 283, 24145-24154.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 3-isobutyryl-1-methylxanthine stimulates activity at 0.1 mM Rattus norvegicus
2.7.11.11 8-bromo-cAMP stimulates activity at 0.1 mM Rattus norvegicus
2.7.11.11 forskolin stimulates activity at 0.025 mM Rattus norvegicus
2.7.11.11 isoproterenol stimulates activity at 2.5 nM Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.11 R96D the mutation mimics phosphorylated regulatory subunit RII Rattus norvegicus
2.7.11.11 RS96A the mutation mimics unphosphorylated regulatory subunit RII Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.11 cytoplasm
-
 Rattus norvegicus 5737
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 cardiomyocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + ryanodine receptor
-
 Rattus norvegicus ADP + phosphorylated ryanodine receptor
-
 ?
2.7.11.11 additional information autophosphorylation of the PKA type II regulatory subunit (RII) can alter its affinity for protein kinase A-anchoring proteins and the catalytic subunit of PKA, RII phosphorylation regulates PKA-dependent substrate phosphorylation and may have significant implications for modulation of cardiac function Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Rattus norvegicus
2.7.11.11 protein kinase A
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Rattus norvegicus
2.7.11.11 cAMP dependent Rattus norvegicus