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Literature summary extracted from

  • Jiang, L.I.; Collins, J.; Davis, R.; Fraser, I.D.; Sternweis, P.C.
    Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII (2008), J. Biol. Chem., 283, 23429-23439.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 isoproterenol stimulates Homo sapiens
4.6.1.1 additional information no stimulation by sphingosine 1-phosphate in HEK 293 cells but synergistic effect on isoproterenol activation, overview Homo sapiens
4.6.1.1 sphingosine 1-phosphate stimulates Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.1 cloning of AC7 cDNA from HEL cells Homo sapiens
4.6.1.1 gene Adcy7 encoding isozyme AC7 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.1 additional information RNAi is used to knockdown each of the four AC isozymes AC2, AC3, AC7, and AC9 specifically and individually in RAW 264.7 cells, bone marrow-derived macrophage from AC7 knockout mice are devoid of an sphingosine 1-phosphate effect on cAMP stimulated by Gs-dependent pathways, but exogenous expression of AC7, while not of AC2, is sufficient to recapitulate the sphingosine 1-phosphate/G13 effect on intracellular cAMP responses. Regulation of the Gs-stimulated cAMP responses by the Gi and Gq/Ca2+ pathways is affected in AC7-deficient cells, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.1 ATP Homo sapiens
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
4.6.1.1 ATP Homo sapiens isozyme AC7 is a key regulator for integration of the S1P/G13 effect on cAMP in RAW 264.7 cells, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
4.6.1.1 additional information Homo sapiens a synergism between the Gs and G13 pathways, mediated by the S1P2 receptor and the heterotrimeric G protein G13, occurs through regulation of a specific isoform of adenylyl cyclase, G13 regulation of AC7 activity is mediated by its alpha-subunit, overview ?
-
 ?
4.6.1.1 additional information Homo sapiens a synergism between the Gs and G13 pathways, mediated by the S1P2 receptor and the heterotrimeric G protein G13, occurs through regulation of a specific isoform of adenylyl cyclase, G13 regulation of AC7 activity is mediated by its alpha-subunit, overview. Overexpression of Galpha12/13QL is unlikely to regulate the activity of Gs, rather it acts to attenuate the G13 pathway that converges on AC7 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Homo sapiens P51828 gene Adcy7 encoding isozyme AC7
-
4.6.1.1 Homo sapiens P51829
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 HEK-293 cell
-
 Homo sapiens
-
4.6.1.1 HEL cell erythroleukemia cell line, high expression of isozyme AC7 Homo sapiens
-
4.6.1.1 RAW-264.7 cell a macrophage-like cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?
4.6.1.1 ATP isozyme AC7 is a key regulator for integration of the S1P/G13 effect on cAMP in RAW 264.7 cells, overview Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?
4.6.1.1 additional information a synergism between the Gs and G13 pathways, mediated by the S1P2 receptor and the heterotrimeric G protein G13, occurs through regulation of a specific isoform of adenylyl cyclase, G13 regulation of AC7 activity is mediated by its alpha-subunit, overview Homo sapiens ?
-
 ?
4.6.1.1 additional information a synergism between the Gs and G13 pathways, mediated by the S1P2 receptor and the heterotrimeric G protein G13, occurs through regulation of a specific isoform of adenylyl cyclase, G13 regulation of AC7 activity is mediated by its alpha-subunit, overview. Overexpression of Galpha12/13QL is unlikely to regulate the activity of Gs, rather it acts to attenuate the G13 pathway that converges on AC7 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 AC7
-
 Homo sapiens
4.6.1.1 adenylyl cyclase VII
-
 Homo sapiens