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Literature summary extracted from

  • Whelan, S.A.; Lane, M.D.; Hart, G.W.
    Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling (2008), J. Biol. Chem., 283, 21411-21417.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.255 Insulin tyrosine phosphorylation of OGT increases significantly after a 10 min insulin treatment Mus musculus
2.4.1.255 additional information insulin signaling stimulates tyrosine phosphorylation of OGT, increases its catalytic activity, affects OGT localization, and results in the O-GlcNAc modification of STAT3, a key kinase and transcription factor in 3T3-L1 adipocytes Mus musculus
2.4.1.255 vanadate tyrosine phosphatase inhibitor sodium vanadate, treatment increases OGT activity. When insulin is added to cells preincubated with sodium vanadate, there is a further increase in OGT activity versus inhibitor alone Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.255 modified with both O-GlcNAc and tyrosine phosphorylation when overexpressed in insect cells Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.255 additional information Mus musculus enzyme catalyzes the addition of O-linked beta-N-acetylglucosamine (O-GlcNAc) onto serine and threonine residues in response to stimuli or stress analogous to phosphorylation by Ser/Thr-kinases ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.255 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.255
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.255 3T3-L1 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.255 additional information enzyme catalyzes the addition of O-linked beta-N-acetylglucosamine (O-GlcNAc) onto serine and threonine residues in response to stimuli or stress analogous to phosphorylation by Ser/Thr-kinases Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.255 O-GlcNAc transferase
-
 Mus musculus
2.4.1.255 O-linked beta-N-acetylglucosamine transferase
-
 Mus musculus
2.4.1.255 OGT
-
 Mus musculus