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Literature summary extracted from

  • Chen, B.B.; Mallampalli, R.K.
    Calmodulin binds and stabilizes the regulatory enzyme, CTP:phosphocholine cytidylyltransferase (2007), J. Biol. Chem., 282, 33494-33506.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.15 expressed in Escherichia coli Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.15 Q243A the mutation results in loss of calmodulin binding and leads to complete calpain resistance in vitro and in vivo Mus musculus

General Stability

EC Number General Stability Organism
2.7.7.15 calmodulin stabilizes CCTalpha from calpain proteolysis Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.15 calpain calpain degrades CCTalpha, 0.6 pmol of calpain effectively cleaves 80% of purified CCTalpha (0.7 pmol) in the absence of calmodulin Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.15 30000
-
 1 * 80000 + 1 * 30000 Mus musculus
2.7.7.15 80000
-
 1 * 80000 + 1 * 30000 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + choline phosphate
-
 Mus musculus diphosphate + CDP-choline
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.15 heterodimer 1 * 80000 + 1 * 30000 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.7.15 CCTalpha
-
 Mus musculus
2.7.7.15 CTP:phosphocholine cytidylyltransferase
-
 Mus musculus