Any feedback?
Literature summary extracted from
- UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells (2007), J. Biol. Chem., 282, 33466-33474.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.4.1.17 | isozyme UGT2B15, sequence comparisons, realtime PCR expression analysis | Homo sapiens |
| 2.4.1.17 | isozyme UGT2B17, sequence comparisons, realtime PCR expression analysis | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 2.4.1.17 | additional information | suppression of isozyme UGT2B15 by RNAsi leading to 70% reduction of the UGT mRNA levels and over 75% reduction of glucuronidation of androgens in prostate cancer LNCaP cells | Homo sapiens |
| 2.4.1.17 | additional information | suppression of isozyme UGT2B17 by RNAsi leading to 70% reduction of the UGT mRNA levels and over 75% reduction of glucuronidation of androgens in prostate cancer LNCaP cells | Homo sapiens |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.4.1.17 | Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.1.17 | additional information | Homo sapiens | isozyme UGT2B15 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | ? | - |
? | |
| 2.4.1.17 | additional information | Homo sapiens | isozyme UGT2B17 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | ? | - |
? | |
| 2.4.1.17 | UDP-D-glucuronate + androstane-3alpha,17beta-diol | Homo sapiens | in epithelial cells of the human prostate | UDP + ? | - |
? | |
| 2.4.1.17 | UDP-D-glucuronate + androsterone | Homo sapiens | in epithelial cells of the human prostate | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
| 2.4.1.17 | UDP-D-glucuronate + dihydrotestosterone | Homo sapiens | in epithelial cells of the human prostate | UDP + dihydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.4.1.17 | Homo sapiens | O75795 | isozyme UGT2B17; isozyme UGT2B17 | - |
| 2.4.1.17 | Homo sapiens | P54855 | isozyme UGT2B15; isozyme UGT2B15 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.4.1.17 | epithelial cell | - |
Homo sapiens | - |
| 2.4.1.17 | LNCaP cell | - |
Homo sapiens | - |
| 2.4.1.17 | prostate cancer cell | - |
Homo sapiens | - |
| 2.4.1.17 | prostate gland | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.1.17 | additional information | isozyme UGT2B15 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | Homo sapiens | ? | - |
? | |
| 2.4.1.17 | additional information | isozyme UGT2B17 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | Homo sapiens | ? | - |
? | |
| 2.4.1.17 | UDP-D-glucuronate + androstane-3alpha,17beta-diol | - |
Homo sapiens | UDP + ? | - |
? | |
| 2.4.1.17 | UDP-D-glucuronate + androstane-3alpha,17beta-diol | in epithelial cells of the human prostate | Homo sapiens | UDP + ? | - |
? | |
| 2.4.1.17 | UDP-D-glucuronate + androsterone | - |
Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
| 2.4.1.17 | UDP-D-glucuronate + androsterone | in epithelial cells of the human prostate | Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
| 2.4.1.17 | UDP-D-glucuronate + dihydrotestosterone | - |
Homo sapiens | UDP + dihydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
| 2.4.1.17 | UDP-D-glucuronate + dihydrotestosterone | in epithelial cells of the human prostate | Homo sapiens | UDP + dihydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.4.1.17 | UDP-glucuronosyltransferase 2B15 | - |
Homo sapiens |
| 2.4.1.17 | UDP-glucuronosyltransferase 2B17 | - |
Homo sapiens |
| 2.4.1.17 | UGT2B15 | - |
Homo sapiens |
| 2.4.1.17 | UGT2B17 | - |
Homo sapiens |
| 2.4.1.17 | uridine diphosphate-glucuronosyltransferase 2 B15 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 2.4.1.17 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 2.4.1.17 | 7.4 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
