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Literature summary extracted from

  • Järvinen, A.; Grigorenko, N.; Khomutov, A.R.; Hyvönen, M.T.; Uimari, A.; Vepsäläinen, J.; Sinervirta, R.; Keinänen, T.A.; Vujcic, S.; Alhonen, L.; Porter, C.W.; Jänne, J.
    Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines. (2005), J. Biol. Chem., 280, 6595-6601.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.3.13 0.0093
-
spermine addition of 5 mM benzyldehyde, hPAO Homo sapiens
1.5.3.13 0.011
-
alpha-methylspermine without benzyladehyde, kinetic value for the methylated end, hPAO Homo sapiens
1.5.3.13 0.012
-
alpha-methylspermine without benzyladehyde, kinetic value for the unmethylated end, hPAO Homo sapiens
1.5.3.13 0.014
-
N1-acetylspermidine without benzyladehyde, hPAO Homo sapiens
1.5.3.13 0.015
-
spermidine addition of 5 mM benzyldehyde, hPAO Homo sapiens
1.5.3.13 0.016
-
alpha-methylspermidine addition of 5 mM benzyldehyde, hPAO Homo sapiens
1.5.3.13 0.017
-
alpha-methylspermine without benzyladehyde, kinetic value for the methylated end, hPAO Homo sapiens
1.5.3.13 0.019
-
alpha-methylspermine without benzyladehyde, kinetic value for the unmethylated end, hPAO Homo sapiens
1.5.3.13 0.028
-
N1-acetylspermidine addition of 5 mM benzyldehyde, hPAO Homo sapiens
1.5.3.13 0.047
-
spermine without benzyladehyde, hPAO Homo sapiens
1.5.3.16 0.02
-
spermine hSMO Homo sapiens
1.5.3.16 0.034
-
alpha-methylspermine without benzyladehyde, kinetic value for the unmethylated end, hSMO Homo sapiens
1.5.3.16 0.067
-
alpha-methylspermine without benzyladehyde, kinetic value for the unmethylated end, hSMO Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.13 Homo sapiens
-
-
-
1.5.3.16 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.3.13 hPAO Homo sapiens
1.5.3.16
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.13 alpha-methylspermidine + O2 + H2O weak oxidation in presence of benzaldehyde, no oxidation without benzaldehyde Homo sapiens ?
-
?
1.5.3.13 alpha-methylspermine + O2 + H2O oxidation in presence of benzaldehyde, no oxidation without benzaldehyde Homo sapiens ?
-
?
1.5.3.13 additional information no production of spermidine from bis-alpha-methylspermine, hPAO Homo sapiens ?
-
?
1.5.3.13 N1-acetylspermidine + O2 + H2O strongly preferred substrat, hPAO Homo sapiens ?
-
?
1.5.3.13 spermidine + O2 + H2O weak oxidation in presence of benzaldehyde, no oxidation without benzaldehyde Homo sapiens ?
-
?
1.5.3.13 spermine + O2 + H2O oxidation in presence of benzaldehyde, no oxidation without benzaldehyde Homo sapiens ?
-
?
1.5.3.16 alpha-methylspermine + O2 + H2O
-
Homo sapiens ?
-
?
1.5.3.16 additional information no activity with N1-acetylspermine, spermidine, alpha-methylspermidine. No production of spermidine from bis-alpha-methylspermine, hSMO Homo sapiens ?
-
?
1.5.3.16 spermine + O2 + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.5.3.13 HPAO
-
Homo sapiens
1.5.3.16 hSMO
-
Homo sapiens