Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhang, M.
    Chen, W.; Smith, S.M.; Napoli, J.L.: Molecular characterization of a mouse short chain dehydrogenase/reductase active with all-trans-retinol in intact cells, mRDH1 (2001), J. Biol. Chem., 276, 44083-44090.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.105 expression in CHO-K1 cells Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.105 0.0022
-
9-cis-retinol pH 8, 37°C Mus musculus
1.1.1.105 0.0026
-
all-trans-retinol pH 8, 37°C Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.105 all-trans-retinol + NAD+ Mus musculus RDH1 functions in a path of all-trans-retinoic acid biosynthesis starting early during embryogenesis all-trans-retinal + NADH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.105 Mus musculus Q8VIJ7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.105 brain strong mRNA expression Mus musculus
-
1.1.1.105 embryo the mouse embryo expresses RDH1 as early as 7.0 days post-coitus, and expression is especially intense within the neural tube, gut, and neural crest at embryo day 10.5 Mus musculus
-
1.1.1.105 epididymis mRNA expression Mus musculus
-
1.1.1.105 eye mRNA expression Mus musculus
-
1.1.1.105 heart strong mRNA expression Mus musculus
-
1.1.1.105 kidney strong mRNA expression Mus musculus
-
1.1.1.105 liver strong mRNA expression Mus musculus
-
1.1.1.105 lung mRNA expression Mus musculus
-
1.1.1.105 additional information RDH1 has widespread and intense mRNA expression in tissues of embryonic and adult mice Mus musculus
-
1.1.1.105 ovary mRNA expression Mus musculus
-
1.1.1.105 pancreas strong mRNA expression Mus musculus
-
1.1.1.105 prostate mRNA expression Mus musculus
-
1.1.1.105 skeletal muscle strong mRNA expression Mus musculus
-
1.1.1.105 smooth muscle mRNA expression Mus musculus
-
1.1.1.105 submandibular gland strong mRNA expression Mus musculus
-
1.1.1.105 testis strong mRNA expression Mus musculus
-
1.1.1.105 thymus mRNA expression Mus musculus
-
1.1.1.105 thyroid gland mRNA expression Mus musculus
-
1.1.1.105 uterus mRNA expression Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.105 9-cis-retinol + NAD+ higher activity with all-trans-retinol versus 9-cis-retinol Mus musculus 9-cis-retinal + NADH + H+
-
?
1.1.1.105 all-trans-retinol + NAD+ RDH1 functions in a path of all-trans-retinoic acid biosynthesis starting early during embryogenesis Mus musculus all-trans-retinal + NADH + H+
-
?
1.1.1.105 all-trans-retinol + NAD+ RDH1 has 8–11fold higher activity with NAD+ versus NADP+. Higher activity with all-trans-retinol versus 9-cis-retinol. Multifunctional enzyme. In addition to retinol dehydrogenase activity, RDH1 has strong 3alpha-hydroxy and weak 17beta-hydroxy steroid dehydrogenase activities Mus musculus all-trans-retinal + NADH + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.105 mRDH1 multifunctional enzyme. In addition to retinol dehydrogenase activity, RDH1 has strong 3alpha-hydroxy and weak 17beta-hydroxy steroid dehydrogenase activities Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.105 8
-
-
Mus musculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.105 7.5 8 pH 7.5: 54% of maximal activity, pH 8: maximal activity Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.105 NAD+ RDH1 has 8–11fold higher activity with NAD+ versus NADP+ Mus musculus
1.1.1.105 NADP+ RDH1 has 8–11fold higher activity with NAD+ versus NADP+ Mus musculus