EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.105 | expression in CHO-K1 cells | Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.105 | 0.0022 | - |
9-cis-retinol | pH 8, 37°C | Mus musculus | |
1.1.1.105 | 0.0026 | - |
all-trans-retinol | pH 8, 37°C | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.105 | all-trans-retinol + NAD+ | Mus musculus | RDH1 functions in a path of all-trans-retinoic acid biosynthesis starting early during embryogenesis | all-trans-retinal + NADH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.105 | Mus musculus | Q8VIJ7 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.105 | brain | strong mRNA expression | Mus musculus | - |
1.1.1.105 | embryo | the mouse embryo expresses RDH1 as early as 7.0 days post-coitus, and expression is especially intense within the neural tube, gut, and neural crest at embryo day 10.5 | Mus musculus | - |
1.1.1.105 | epididymis | mRNA expression | Mus musculus | - |
1.1.1.105 | eye | mRNA expression | Mus musculus | - |
1.1.1.105 | heart | strong mRNA expression | Mus musculus | - |
1.1.1.105 | kidney | strong mRNA expression | Mus musculus | - |
1.1.1.105 | liver | strong mRNA expression | Mus musculus | - |
1.1.1.105 | lung | mRNA expression | Mus musculus | - |
1.1.1.105 | additional information | RDH1 has widespread and intense mRNA expression in tissues of embryonic and adult mice | Mus musculus | - |
1.1.1.105 | ovary | mRNA expression | Mus musculus | - |
1.1.1.105 | pancreas | strong mRNA expression | Mus musculus | - |
1.1.1.105 | prostate | mRNA expression | Mus musculus | - |
1.1.1.105 | skeletal muscle | strong mRNA expression | Mus musculus | - |
1.1.1.105 | smooth muscle | mRNA expression | Mus musculus | - |
1.1.1.105 | submandibular gland | strong mRNA expression | Mus musculus | - |
1.1.1.105 | testis | strong mRNA expression | Mus musculus | - |
1.1.1.105 | thymus | mRNA expression | Mus musculus | - |
1.1.1.105 | thyroid gland | mRNA expression | Mus musculus | - |
1.1.1.105 | uterus | mRNA expression | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.105 | 9-cis-retinol + NAD+ | higher activity with all-trans-retinol versus 9-cis-retinol | Mus musculus | 9-cis-retinal + NADH + H+ | - |
? | |
1.1.1.105 | all-trans-retinol + NAD+ | RDH1 functions in a path of all-trans-retinoic acid biosynthesis starting early during embryogenesis | Mus musculus | all-trans-retinal + NADH + H+ | - |
? | |
1.1.1.105 | all-trans-retinol + NAD+ | RDH1 has 811fold higher activity with NAD+ versus NADP+. Higher activity with all-trans-retinol versus 9-cis-retinol. Multifunctional enzyme. In addition to retinol dehydrogenase activity, RDH1 has strong 3alpha-hydroxy and weak 17beta-hydroxy steroid dehydrogenase activities | Mus musculus | all-trans-retinal + NADH + H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.105 | mRDH1 | multifunctional enzyme. In addition to retinol dehydrogenase activity, RDH1 has strong 3alpha-hydroxy and weak 17beta-hydroxy steroid dehydrogenase activities | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.105 | 8 | - |
- |
Mus musculus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.105 | 7.5 | 8 | pH 7.5: 54% of maximal activity, pH 8: maximal activity | Mus musculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.105 | NAD+ | RDH1 has 811fold higher activity with NAD+ versus NADP+ | Mus musculus | |
1.1.1.105 | NADP+ | RDH1 has 811fold higher activity with NAD+ versus NADP+ | Mus musculus |