Literature summary extracted from

Augustine, L.M.; Fisher, C.D.; Lickteig, A.J.; Aleksunes, L.M.; Slitt, A.L.; Cherrington, N.J.
Gender divergent expression of Nqo1 in Sprague Dawley and August Copenhagen x Irish rats (2008), J. Biochem. Mol. Toxicol., 22, 93-100.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.6.5.2	butylated hydroxyanisole	inducer	Rattus norvegicus
1.6.5.2	oltipraz	inducer	Rattus norvegicus

Application

EC Number	Application	Comment	Organism
1.6.5.2	medicine	strain difference where Sprague Dawley rats possess a sex-dependent expression and activity of Nqo1 and August Copenhagen x Irish rats exhibit no sexual dimorphism may provide an important tool when using these rat models for oxidative stress and cancer studies	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.6.5.2	cytosol	-	Rattus norvegicus	5829	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.6.5.2	32000	-	Western blot analysis	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.6.5.2	Rattus norvegicus	-	Sprague Dawley and August Copenhagen x Irish strains	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.6.5.2	liver	in the Sprague Dawley strain, gender dimorphic expression of Nqo1 with female mRNA, protein, and activity levels being significantly higher than in males. Minimal differences in Nqo1 mRNA, protein, and activity levels between August Copenhagen x Irish males and females	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.6.5.2	NADPH + H+ + oxidized 2,6-dichlorophenolindophenol	-	Rattus norvegicus	NADP+ + reduced 2,6-dichlorophenolindophenol	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.6.5.2	NAD(P)H:quinone oxidoreducatase 1	-	Rattus norvegicus
1.6.5.2	NQO1	-	Rattus norvegicus

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Release 2023.1 (January 2023)