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Literature summary extracted from

  • Pope, S.D.; Chen, L.L.; Stewart, V.
    Purine utilization by Klebsiella oxytoca M5al: genes for ring-oxidizing and -opening enzymes (2008), J. Bacteriol., 191, 1006-1017.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.13.113
-
 Klebsiella oxytoca

Protein Variants

EC Number Protein Variants Comment Organism
5.1.99.3 additional information gene insertion mutant, gene hpxA is not essential for growth on allantoin Klebsiella oxytoca

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.1.99.3 25578
-
 x * 25578, calculated Klebsiella oxytoca

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.113 urate + NADH + H+ + O2 Klebsiella oxytoca part of the purine catabolic pathway 5-hydroxyisourate + NAD+ + H2O
-
 ?
1.14.13.113 urate + NADH + H+ + O2 Klebsiella oxytoca M5al part of the purine catabolic pathway 5-hydroxyisourate + NAD+ + H2O
-
 ?
5.1.99.3 (S)-allantoin Klebsiella michiganensis M5al
-
 (R)-allantoin
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.113 Klebsiella oxytoca B5B0J6
-
-
1.14.13.113 Klebsiella oxytoca M5al B5B0J6
-
-
5.1.99.3 Klebsiella michiganensis M5al B5B0K3
-
-
5.1.99.3 Klebsiella oxytoca B5B0K3 gene hpxA is not essential for growth on allantoin
-
5.1.99.3 Klebsiella oxytoca M5al B5B0K3 gene hpxA is not essential for growth on allantoin
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.113 urate + NADH + H+ + O2 part of the purine catabolic pathway Klebsiella oxytoca 5-hydroxyisourate + NAD+ + H2O
-
 ?
1.14.13.113 urate + NADH + H+ + O2 part of the purine catabolic pathway Klebsiella oxytoca M5al 5-hydroxyisourate + NAD+ + H2O
-
 ?
5.1.99.3 (S)-allantoin
-
 Klebsiella michiganensis M5al (R)-allantoin
-
 r

Subunits

EC Number Subunits Comment Organism
5.1.99.3 ? x * 25578, calculated Klebsiella oxytoca

Synonyms

EC Number Synonyms Comment Organism
1.14.13.113 HpxO enzyme
-
 Klebsiella oxytoca
5.1.99.3 allantoin racemase
-
 Klebsiella michiganensis M5al
5.1.99.3 HpxA
-
 Klebsiella oxytoca
5.1.99.3 HpxA enzyme
-
 Klebsiella michiganensis M5al

Expression

EC Number Organism Comment Expression
5.1.99.3 Klebsiella michiganensis M5al enzyme belong to a 23-gene cluster that encodes the enzymes for utilizing purines as the sole nitrogen source additional information

General Information

EC Number General Information Comment Organism
5.1.99.3 physiological function conversion of allantoin to allantoate is the second of the two ring-opening steps in purine utilization Klebsiella michiganensis M5al