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Literature summary extracted from

  • Saum, S.H.; Mueller, V.
    Salinity-dependent switching of osmolyte strategies in a moderately halophilic bacterium: glutamate induces proline biosynthesis in Halobacillus halophilus (2007), J. Bacteriol., 189, 6968-6975.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.41 additional information cellular mRNA levels are increased up to 90fold in the presence of glutamate. A minimal concentration of 0.2 M glutamate already stimulates proA gene expression Halobacillus halophilus

Application

EC Number Application Comment Organism
1.2.1.41 additional information the genes proH encoding pyrroline-5-carboxylate reductase, proJ encoding glutamate-5-kinase, and proA encoding glutamate-5-semialdehyde dehydrogenase form a transcriptional unit. This pro operon is involved in salinity-induced proline biosynthesis Halobacillus halophilus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.41 additional information expression of the proA gene is salinity-dependent and reaches a maximum at 2.5 M NaCl Halobacillus halophilus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.41 Halobacillus halophilus A7Y114 strain DSMZ 2266T
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.41 L-glutamate 5-semialdehyde + phosphate + NADP+
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 Halobacillus halophilus L-5-glutamyl phosphate + NADPH + H+
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