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Literature summary extracted from

  • Merkx-Jacques, A.; Obhi, R.K.; Bethune, G.; Creuzenet, C.
    The Helicobacter pylori flaA1 and wbpB genes control lipopolysaccharide and flagellum synthesis and function (2004), J. Bacteriol., 186, 2253-2265.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.115 gene flaA1, DNA and amino acid sequence determination, expression analysis Helicobacter pylori

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.115 additional information construction of flaA1 knockout mutant by gene disruption in strain NCTC 11637, the nonmotile mutant exhibits altered lipopolysaccharides, with loss of most O-antigen and core modification, and increased sensitivity to sodium dodecyl sulfate compared to wild-type bacteria. The flaA1 mutant produces flagellins but no flagellum. Phynotype, detailed overview Helicobacter pylori

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.115 additional information Helicobacter pylori the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in lipopolysaccharide and flagellum production with glycosylation regulating the activity of these proteins ?
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?
4.2.1.115 additional information Helicobacter pylori the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in LPS and flagellum production with glycosylation regulating the activity of these proteins ?
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?
4.2.1.115 additional information Helicobacter pylori SS1 the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in LPS and flagellum production with glycosylation regulating the activity of these proteins ?
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?
4.2.1.115 additional information Helicobacter pylori NCTC 11637 the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in lipopolysaccharide and flagellum production with glycosylation regulating the activity of these proteins ?
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?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.115 Helicobacter pylori Q6VYQ5 gene flaA1
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4.2.1.115 Helicobacter pylori Q6VYQ6
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4.2.1.115 Helicobacter pylori NCTC 11637 Q6VYQ6
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4.2.1.115 Helicobacter pylori SS1 Q6VYQ5 gene flaA1
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.115 additional information the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in lipopolysaccharide and flagellum production with glycosylation regulating the activity of these proteins Helicobacter pylori ?
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?
4.2.1.115 additional information the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in LPS and flagellum production with glycosylation regulating the activity of these proteins Helicobacter pylori ?
-
?
4.2.1.115 additional information the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in LPS and flagellum production with glycosylation regulating the activity of these proteins Helicobacter pylori SS1 ?
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?
4.2.1.115 additional information the enzyme is involved in lipopolysaccharide biosynthesis, flagellum assembly, or protein glycosylation, and might play an important role in the pathogenesis of Helicobacter pylori. It is at the interface between several pathways that govern the expression of different virulence factors synthesizing sugar derivatives dedicated to the glycosylation of proteins which are involved in lipopolysaccharide and flagellum production with glycosylation regulating the activity of these proteins Helicobacter pylori NCTC 11637 ?
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?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.115 FlaA1
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Helicobacter pylori