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Literature summary extracted from

  • Jiang, J.; Cane, D.E.
    Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin (2008), J. Am. Chem. Soc., 130, 428-429.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.3.22 Mg2+
-
Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.22 additional information Streptomyces coelicolor catalyzes the Mg2+-dependent cyclization of conversion of farnesyl diphosphate to a mixture of germacradienol, germacrene D, and geosmin, accompanied by small amounts of octalin ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.16 Streptomyces coelicolor Q9X839 C-terminal domain; germacradienol/germacrene D synthase
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4.2.3.22 Streptomyces coelicolor
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.99.16 (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone conversion of germacradienol to geosmin results in the release of the three-carbon side chain as acetone and involves a 1,2-hydride shift of the bridgehead hydrogen exclusively into ring B of geosmin Streptomyces coelicolor

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.16 (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O catalysed by the C-terminal domain of the bifunctional enzyme Streptomyces coelicolor (-)-geosmin + acetone
-
?
4.1.99.16 additional information conversion of germacradienol to geosmin results in the release of the three-carbon side chain as acetone and involves a 1,2-hydride shift of the bridgehead hydrogen exclusively into ring B of geosmin Streptomyces coelicolor ?
-
?
4.2.3.22 additional information catalyzes the Mg2+-dependent cyclization of conversion of farnesyl diphosphate to a mixture of germacradienol, germacrene D, and geosmin, accompanied by small amounts of octalin Streptomyces coelicolor ?
-
?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.22 germacradienol synthase
-
Streptomyces coelicolor
4.2.3.22 germacradienol/geosmin synthase
-
Streptomyces coelicolor