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Literature summary extracted from

  • Balg, C.; Huot, J.L.; Lapointe, J.; Chenevert, R.
    Inhibition of Helicobacter pylori Aminoacyl-tRNA Amidotransferase by Puromycin Analogues (2008), J. Am. Chem. Soc., 130, 3264-3265.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.7 3'-(L-alpha-aspartylamino)-3'-deoxy-N,N-dimethyladenosine puromycin analogue Helicobacter pylori
6.3.5.7 3'-deoxy-3'-(L-alpha-glutamylamino)-N,N-dimethyladenosine puromycin analogue Helicobacter pylori
6.3.5.7 3'-deoxy-3'-(L-glutaminylamino)-N,N-dimethyladenosine puromycin analogue Helicobacter pylori
6.3.5.7 3'-[[(2S)-2-amino-4-(methylsulfinyl)butanoyl]amino]-3'-deoxy-N,N-dimethyladenosine puromycin analogue Helicobacter pylori
6.3.5.7 3'-[[(2S)-2-amino-4-(methylsulfonyl)butanoyl]amino]-3'-deoxy-N,N-dimethyladenosine puromycin analogue Helicobacter pylori
6.3.5.7 3'-[[(2S)-4-carboxy-2-hydroxybutanoyl]amino]-3'-deoxy-N,N-dimethyladenosine puromycin analogue Helicobacter pylori
6.3.5.7 3'-[[2-amino-4-(methylphosphinato)butanoyl]amino]-3'-deoxy-N,N-dimethyladenosine puromycin analogue Helicobacter pylori
6.3.5.7 puromycin aminonucleoside antibiotic produced by Streptomyces alboniger, very weak inhibitor of AdT Helicobacter pylori

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.5.7 ATP + Asp-tRNAAsn + L-glutamine Helicobacter pylori
-
 ADP + phosphate + Asn-tRNAAsn + L-glutamate
-
 ?
6.3.5.7 ATP + Glu-tRNAGln + L-glutamine Helicobacter pylori
-
 ADP + phosphate + Gln-tRNAGln + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.7 Helicobacter pylori
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.7 ATP + Asp-tRNAAsn + L-glutamine
-
 Helicobacter pylori ADP + phosphate + Asn-tRNAAsn + L-glutamate
-
 ?
6.3.5.7 ATP + Glu-tRNAGln + L-glutamine
-
 Helicobacter pylori ADP + phosphate + Gln-tRNAGln + L-glutamate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.5.7 heterotrimer
-
 Helicobacter pylori

Synonyms

EC Number Synonyms Comment Organism
6.3.5.7 aa-tRNA amidotransferase
-
 Helicobacter pylori
6.3.5.7 AdT
-
 Helicobacter pylori
6.3.5.7 aminoacyl-tRNA amidotransferase
-
 Helicobacter pylori
6.3.5.7 GatCAB amidotransferase
-
 Helicobacter pylori

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.3.5.7 0.004
-
 3'-[[(2S)-2-amino-4-(methylsulfonyl)butanoyl]amino]-3'-deoxy-N,N-dimethyladenosine
-
 Helicobacter pylori
6.3.5.7 0.011
-
 3'-[[(2S)-2-amino-4-(methylsulfinyl)butanoyl]amino]-3'-deoxy-N,N-dimethyladenosine
-
 Helicobacter pylori
6.3.5.7 0.033
-
 3'-[[2-amino-4-(methylphosphinato)butanoyl]amino]-3'-deoxy-N,N-dimethyladenosine
-
 Helicobacter pylori
6.3.5.7 0.045
-
 3'-deoxy-3'-(L-glutaminylamino)-N,N-dimethyladenosine
-
 Helicobacter pylori
6.3.5.7 0.105
-
 3'-deoxy-3'-(L-alpha-glutamylamino)-N,N-dimethyladenosine
-
 Helicobacter pylori
6.3.5.7 0.13
-
 3'-[[(2S)-4-carboxy-2-hydroxybutanoyl]amino]-3'-deoxy-N,N-dimethyladenosine
-
 Helicobacter pylori
6.3.5.7 0.134
-
 3'-(L-alpha-aspartylamino)-3'-deoxy-N,N-dimethyladenosine
-
 Helicobacter pylori
6.3.5.7 4.1
-
 puromycin very weak inhibitor of AdT Helicobacter pylori