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Literature summary extracted from

  • Rock, W.; Rosenblat, M.; Miller-Lotan, R.; Levy, A.P.; Elias, M.; Aviram, M.
    Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities (2008), J. Agric. Food Chem., 56, 8704-8713.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.2 additional information pomegranate juice and pomegranate polyphenol extract (from variety Wonderful) consumption contributes to PON1 stabilization, increased association with high density lipoprotein, and enhanced catalytic activity Homo sapiens
3.1.1.25 additional information pomegranate juice and pomegranate polyphenol extract (from variety Wonderful) consumption contributes to PON1 stabilization, increased association with high density lipoprotein, and enhanced catalytic activity Homo sapiens
3.1.8.1 additional information pomegranate juice and pomegranate polyphenol extract (from variety Wonderful) consumption contributes to PON1 stabilization, increased association with high density lipoprotein, and enhanced catalytic activity Homo sapiens

General Stability

EC Number General Stability Organism
3.1.1.2 association of paraoxonase 1 with high-density lipoprotein stabilizes the enzyme Homo sapiens
3.1.1.25 association of paraoxonase 1 with high-density lipoprotein stabilizes the enzyme Homo sapiens
3.1.8.1 association of paraoxonase 1 with high-density lipoprotein stabilizes the enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.2 nitrilotriacetic acid
-
 Homo sapiens
3.1.1.25 nitrilotriacetic acid
-
 Homo sapiens
3.1.8.1 nitrilotriacetic acid
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens P27169
-
-
3.1.1.25 Homo sapiens P27169
-
-
3.1.8.1 Homo sapiens P27169
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.2 serum
-
 Homo sapiens
-
3.1.1.25 serum
-
 Homo sapiens
-
3.1.8.1 serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 additional information the enzyme contains arylesterase, paraoxonase, and lactonase activities Homo sapiens ?
-
 ?
3.1.1.2 phenyl acetate + H2O
-
 Homo sapiens phenol + acetate
-
 ?
3.1.1.25 dihydrocoumarin + H2O weak activity Homo sapiens 3-(2-hydroxyphenyl)-propionic acid
-
 ?
3.1.1.25 additional information contains arylesterase, paraoxonase, and lactonase activities Homo sapiens ?
-
 ?
3.1.1.25 thiobutyl butyrolactone + H2O
-
 Homo sapiens ?
-
 ?
3.1.8.1 paraoxon + H2O highest activity Homo sapiens diethylphosphate + 4-nitrophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.8.1 paraoxonase 1
-
 Homo sapiens
3.1.8.1 PON1 contains arylesterase, paraoxonase, and lactonase activities Homo sapiens