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Literature summary extracted from

  • Maschi, O.; Cero, E.D.; Galli, G.V.; Caruso, D.; Bosisio, E.; DellAgli, M.
    Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L (2008), J. Agric. Food Chem., 56, 5015-5020.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.35 chamomile weak, but still statistically significant inhibition of PDE5A1 Homo sapiens
3.1.4.35 sildenafil 70% inhibition at 100 nM Homo sapiens
3.1.4.53 apigenin
-
 Homo sapiens
3.1.4.53 apigenin-7-O-glucoside
-
 Homo sapiens
3.1.4.53 chamomile inhibits cAMP-PDE activity Homo sapiens
3.1.4.53 hyperoside
-
 Homo sapiens
3.1.4.53 luteolin
-
 Homo sapiens
3.1.4.53 luteolin-7-O-glucoside
-
 Homo sapiens
3.1.4.53 additional information not inhibited by alpha-bisabolol, caffeic acid, ferulic acid, quinic acid, rutin, chlorogenic acid, herniarin, and umbelliferone Homo sapiens
3.1.4.53 patuletin-7-O-glucoside
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.35 Homo sapiens
-
-
-
3.1.4.53 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.35 blood platelet
-
 Homo sapiens
-
3.1.4.53 blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.35 3',5'-cGMP + H2O
-
 Homo sapiens 5'-GMP
-
 ?
3.1.4.53 3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.35 cGMP-PDE
-
 Homo sapiens
3.1.4.35 cGMP-phosphodiesterase
-
 Homo sapiens
3.1.4.35 PDE5A1 recombinant enzyme Homo sapiens
3.1.4.53 cAMP-PDE
-
 Homo sapiens
3.1.4.53 cAMP-phosphodiesterase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.53 0.0013
-
-
 Homo sapiens luteolin
3.1.4.53 0.0041
-
-
 Homo sapiens apigenin
3.1.4.53 0.0102
-
-
 Homo sapiens apigenin-7-O-glucoside
3.1.4.53 0.0118
-
-
 Homo sapiens hyperoside
3.1.4.53 0.0149
-
-
 Homo sapiens luteolin-7-O-glucoside
3.1.4.53 0.0149
-
-
 Homo sapiens patuletin-7-O-glucoside