Literature summary extracted from

Keskin, M.; Dolar, E.; Dirican, M.; Kiyici, M.; Yilmaz, Y.; Gurel, S.; Nak, S.G.; Erdinc, S.; Gulten, M.
Baseline and salt-stimulated paraoxonase and arylesterase activities in patients with chronic liver disease: Relation with disease severity (2009), Intern. Med. J., 39, 243-248.

Application

EC Number	Application	Comment	Organism
3.1.1.2	medicine	baseline and stimulated ARE activity is significantly lower in patients with chronic liver disease than in controls, serum ARE activity can be a suitable biomarker for the evaluation of the presence and severity of chronic liver damage	Homo sapiens
3.1.1.2	medicine	serum ARE activity may be a suitable biomarker for identifying the presence and severity of chronic liver injury	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.2	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.1.2	serum	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.1.2	4-nitrophenyl acetate + H2O	-	Homo sapiens	4-nitrophenol + acetate	-	?
3.1.1.2	phenyl acetate + H2O	-	Homo sapiens	phenol + acetate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.1.2	ARE	-	Homo sapiens
3.1.1.2	arylesterase	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.1.1.2	physiological function	baseline and stimulated paraoxonase (PON1) and ARE activities are significantly lower in patients with chronic liver disease (by 32%) than in controls. ARE activity is significantly decreased (by 55%) in liver cirrhosis patients. ARE activity is significantly lower (by 35%) in cirrhotic patients compared with the chronic hepatitis group. ARE/high-density lipoprotein and the ARE/apolipoprotein A1 ratios are significantly reduced in patients with chronic hepatitis compared with controls. Similarly, the ARE/high-density lipoprotein and the ARE/apolipoprotein A1 ratios are significantly lower in patients with cirrhosis than in controls	Homo sapiens

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Release 2023.1 (January 2023)