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Literature summary extracted from

  • De Luca, D.; Minucci, A.; Zecca, E.; Piastra, M.; Pietrini, D.; Carnielli, V.P.; Zuppi, C.; Tridente, A.; Conti, G.; Capoluongo, E.D.
    Bile acids cause secretory phospholipase A2 activity enhancement, revertible by exogenous surfactant administration (2009), Intensive Care Med., 35, 321-326.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.4 bile acid bile acids cause sPLA2 activity enhancement, revertible by exogenous surfactant administration, overview. Bile acids are likely to contribute to lung injury, causing surfactant inactivation through the increased sPLA2 activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.4 diheptanoyl phosphatidylcholine + H2O Homo sapiens
-
 1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
-
 ?
3.1.1.4 additional information Homo sapiens bile acids are likely to contribute to lung injury, causing surfactant inactivation through the increased sPLA2 activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 lung broncho-alveolar lavage Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1,2-diheptanoyl phosphatidylcholine + H2O
-
 Homo sapiens 1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
-
 ?
3.1.1.4 diheptanoyl phosphatidylcholine + H2O
-
 Homo sapiens 1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
-
 ?
3.1.1.4 additional information bile acids are likely to contribute to lung injury, causing surfactant inactivation through the increased sPLA2 activity Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 secretory phospholipase A2
-
 Homo sapiens
3.1.1.4 sPLA2
-
 Homo sapiens