Literature summary extracted from

Curtin, K.; Ulrich, C.M.; Samowitz, W.S.; Bigler, J.; Caan, B.; Potter, J.D.; Slattery, M.L.
Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival (2007), Int. J. Cancer, 120, 2226-2232.

Application

EC Number	Application	Comment	Organism
2.1.1.45	medicine	TS is an important target for colorectal cancer therapy	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	Homo sapiens	TS is a key enzyme in folate metabolism	7,8-dihydrofolate + dTMP	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.45	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.45	colonic cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	-	Homo sapiens	7,8-dihydrofolate + dTMP	-	?
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	TS is a key enzyme in folate metabolism	Homo sapiens	7,8-dihydrofolate + dTMP	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)