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Literature summary extracted from

  • Lee, Y.G.; Chain, B.M.; Cho, J.Y.
    Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaBalpha via activation of the phosphoinositide-3-kinase and Akt pathways (2009), Int. J. Biochem. Cell Biol., 41, 811-821.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.10.2 medicine Syk may be a potential target for the development of potent anti-inflammatory drugs Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 piceatannol
-
 Mus musculus
2.7.10.2 siRNA
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.10.2 72000
-
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine Mus musculus
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Mus musculus P48025
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 macrophage
-
 Mus musculus
-
2.7.10.2 peritoneal macrophage
-
 Mus musculus
-
2.7.10.2 RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + KVEKIGEGTYGVVYK substrate peptide used in kinase activity assay, derived from p34cdc2 Mus musculus ? + ADP
-
 ?
2.7.10.2 ATP + [protein]-L-tyrosine
-
 Mus musculus ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Spleen tyrosine kinase
-
 Mus musculus
2.7.10.2 Syk
-
 Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.10.2 7.2
-
 in vitro c-Src kinase activity assay Mus musculus