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Literature summary extracted from

  • Yadava, N.; Potluri, P.; Scheffler, I.E.
    Investigations of the potential effects of phosphorylation of the MWFE and ESSS subunits on complex I activity and assembly (2008), Int. J. Biochem. Cell Biol., 40, 447-460.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.2 additional information if phosphorylation occurs in vivo, effects on complex I activity are significant Cricetulus griseus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.1.1.2 constitutive expression of the tagged wild type, or mutant MWFE or ESSS proteins via a pTRIDENT-neo (tricistronic) vector with the EF1alpha promoter Cricetulus griseus

Protein Variants

EC Number Protein Variants Comment Organism
7.1.1.2 S2A mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity Cricetulus griseus
7.1.1.2 S2A/S8A double mutant of phosphorylated subunit ESSS, mutant protein causes a complete failure to assemble Cricetulus griseus
7.1.1.2 S2E mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity Cricetulus griseus
7.1.1.2 S30A mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity Cricetulus griseus
7.1.1.2 S30E mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity Cricetulus griseus
7.1.1.2 S55A mutant of phosphorylated subunit MWFE, functional complex I can be assembled, mutant protein is expressed at a lower level compared to the wild-type protein Cricetulus griseus
7.1.1.2 S55D mutant of phosphorylated subunit MWFE, assembly of complex I is completely blocked Cricetulus griseus
7.1.1.2 S55E mutant of phosphorylated subunit MWFE, assembly of complex I is completely blocked Cricetulus griseus
7.1.1.2 S55Q mutant of phosphorylated subunit MWFE, assembly of complex I is completely blocked Cricetulus griseus
7.1.1.2 S8A mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity Cricetulus griseus
7.1.1.2 S8E mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity Cricetulus griseus
7.1.1.2 T21A mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity Cricetulus griseus
7.1.1.2 T21E mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity Cricetulus griseus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 rotenone
-
Cricetulus griseus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
Cricetulus griseus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Cricetulus griseus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 additional information CCL16-B2 cell and V79-G18 cell Cricetulus griseus
-

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
Cricetulus griseus
7.1.1.2 NADH-ubiquinone oxidoreductase
-
Cricetulus griseus