EC Number | Application | Comment | Organism |
---|---|---|---|
7.1.1.2 | additional information | if phosphorylation occurs in vivo, effects on complex I activity are significant | Cricetulus griseus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
7.1.1.2 | constitutive expression of the tagged wild type, or mutant MWFE or ESSS proteins via a pTRIDENT-neo (tricistronic) vector with the EF1alpha promoter | Cricetulus griseus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
7.1.1.2 | S2A | mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity | Cricetulus griseus |
7.1.1.2 | S2A/S8A | double mutant of phosphorylated subunit ESSS, mutant protein causes a complete failure to assemble | Cricetulus griseus |
7.1.1.2 | S2E | mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity | Cricetulus griseus |
7.1.1.2 | S30A | mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity | Cricetulus griseus |
7.1.1.2 | S30E | mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity | Cricetulus griseus |
7.1.1.2 | S55A | mutant of phosphorylated subunit MWFE, functional complex I can be assembled, mutant protein is expressed at a lower level compared to the wild-type protein | Cricetulus griseus |
7.1.1.2 | S55D | mutant of phosphorylated subunit MWFE, assembly of complex I is completely blocked | Cricetulus griseus |
7.1.1.2 | S55E | mutant of phosphorylated subunit MWFE, assembly of complex I is completely blocked | Cricetulus griseus |
7.1.1.2 | S55Q | mutant of phosphorylated subunit MWFE, assembly of complex I is completely blocked | Cricetulus griseus |
7.1.1.2 | S8A | mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity | Cricetulus griseus |
7.1.1.2 | S8E | mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity | Cricetulus griseus |
7.1.1.2 | T21A | mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity | Cricetulus griseus |
7.1.1.2 | T21E | mutant of phosphorylated subunit ESSS, shows lower levels of mature protein and a significantly reduced complex I activity | Cricetulus griseus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.1.1.2 | rotenone | - |
Cricetulus griseus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.1.1.2 | mitochondrion | - |
Cricetulus griseus | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.1.1.2 | Cricetulus griseus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
7.1.1.2 | additional information | CCL16-B2 cell and V79-G18 cell | Cricetulus griseus | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.1.1.2 | complex I | - |
Cricetulus griseus |
7.1.1.2 | NADH-ubiquinone oxidoreductase | - |
Cricetulus griseus |