EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.24 | TNF-alpha | p38 MAP kinase is significantly activated by TNF-alpha, however, activation of ERK1/2 and JNK remain essentially unchanged. TNF-alpha-induced phosphorylation of the p38 MAP kinase is inhibited by SB203580 | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.24 | SB203580 | inhibitor of p38 MAP kinase, inhibition of the activation by TNF-alpha | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.24 | Mg2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.24 | ATP + MMP-9 | Homo sapiens | activity of p38 MAP kinase, TNF-alpha stimulates MMP-9 expression via the p38 MAP kinase signaling pathway in 5637 cells, and p38 MAP kinase-mediated MMP-9 gene regulation in response to TNF-alpha is involved in the NF-kappaB response element in 5637 cells, regulation, overview | ADP + phosphorylated MMP-9 | - |
? | |
2.7.11.24 | additional information | Homo sapiens | p38 MAP kinase inhibitor SB203580 decreases TNF-alpha-mediated DNA binding activity of NF-?B, which is is involved in p38MAP kinase-mediated control of the MMP-9 gene in 5637 cells, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.24 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.24 | 5637 cell | urinary bladder cancer cells | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.24 | ATP + MMP-9 | activity of p38 MAP kinase, TNF-alpha stimulates MMP-9 expression via the p38 MAP kinase signaling pathway in 5637 cells, and p38 MAP kinase-mediated MMP-9 gene regulation in response to TNF-alpha is involved in the NF-kappaB response element in 5637 cells, regulation, overview | Homo sapiens | ADP + phosphorylated MMP-9 | - |
? | |
2.7.11.24 | ATP + MMP-9 | activity of p38 MAP kinase | Homo sapiens | ADP + phosphorylated MMP-9 | - |
? | |
2.7.11.24 | additional information | p38 MAP kinase inhibitor SB203580 decreases TNF-alpha-mediated DNA binding activity of NF-?B, which is is involved in p38MAP kinase-mediated control of the MMP-9 gene in 5637 cells, overview | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.24 | p38 MAP kinase | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.24 | ATP | - |
Homo sapiens |