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Literature summary extracted from

  • Lee, S.J.; Park, S.S.; Lee, U.S.; Kim, W.J.; Moon, S.K.
    Signaling pathway for TNF-alpha-induced MMP-9 expression: Mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells (2008), Int. Immunopharmacol., 8, 1821-1826.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 TNF-alpha p38 MAP kinase is significantly activated by TNF-alpha, however, activation of ERK1/2 and JNK remain essentially unchanged. TNF-alpha-induced phosphorylation of the p38 MAP kinase is inhibited by SB203580 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 SB203580 inhibitor of p38 MAP kinase, inhibition of the activation by TNF-alpha Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.24 Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 ATP + MMP-9 Homo sapiens activity of p38 MAP kinase, TNF-alpha stimulates MMP-9 expression via the p38 MAP kinase signaling pathway in 5637 cells, and p38 MAP kinase-mediated MMP-9 gene regulation in response to TNF-alpha is involved in the NF-kappaB response element in 5637 cells, regulation, overview ADP + phosphorylated MMP-9
-
?
2.7.11.24 additional information Homo sapiens p38 MAP kinase inhibitor SB203580 decreases TNF-alpha-mediated DNA binding activity of NF-?B, which is is involved in p38MAP kinase-mediated control of the MMP-9 gene in 5637 cells, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 5637 cell urinary bladder cancer cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 ATP + MMP-9 activity of p38 MAP kinase, TNF-alpha stimulates MMP-9 expression via the p38 MAP kinase signaling pathway in 5637 cells, and p38 MAP kinase-mediated MMP-9 gene regulation in response to TNF-alpha is involved in the NF-kappaB response element in 5637 cells, regulation, overview Homo sapiens ADP + phosphorylated MMP-9
-
?
2.7.11.24 ATP + MMP-9 activity of p38 MAP kinase Homo sapiens ADP + phosphorylated MMP-9
-
?
2.7.11.24 additional information p38 MAP kinase inhibitor SB203580 decreases TNF-alpha-mediated DNA binding activity of NF-?B, which is is involved in p38MAP kinase-mediated control of the MMP-9 gene in 5637 cells, overview Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 p38 MAP kinase
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.24 ATP
-
Homo sapiens