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Literature summary extracted from

  • Camuzcuoglu, H.; Arioz, D.T.; Toy, H.; Kurt, S.; Celik, H.; Erel, O.
    Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer (2009), Gynecol. Oncol., 112, 481-485.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.2 medicine diminished paraoxonase and arylesterase activity is associated with particular stage, grade and CA-125 level of ovarian cancer Homo sapiens
3.1.8.1 medicine diminished paraoxonase and arylesterase activity is associated with particular stage, grade and CA-125 level of ovarian cancer Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.2 Ca2+ dependent on Homo sapiens
3.1.8.1 Ca2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.2 additional information Homo sapiens PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products ?
-
?
3.1.8.1 additional information Homo sapiens PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens P27169
-
-
3.1.8.1 Homo sapiens P27169
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.2 liver the enzyme is synthesized in the liver Homo sapiens
-
3.1.1.2 serum the enzyme is secreted into the serum Homo sapiens
-
3.1.8.1 liver the enzyme is synthesized in the liver Homo sapiens
-
3.1.8.1 serum the enzyme is secreted into the serum Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 additional information PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products Homo sapiens ?
-
?
3.1.1.2 additional information PON1 is an high density lipoprotein-associated enzyme with three activities: paraoxonase, arylesterase and dyazoxonase Homo sapiens ?
-
?
3.1.1.2 phenyl acetate + H2O
-
Homo sapiens phenol + acetate
-
?
3.1.8.1 additional information PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products Homo sapiens ?
-
?
3.1.8.1 paraoxon + H2O
-
Homo sapiens diethylphosphate + 4-nitrophenol
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.2 arylesterase
-
Homo sapiens
3.1.8.1 paraoxonase-1
-
Homo sapiens
3.1.8.1 PON1 PON1 is an high density lipoprotein-associated enzyme with three activities: paraoxonase, arylesterase and dyazoxonase Homo sapiens