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Literature summary extracted from

  • Okuda, T.; Nakayama, K.I.
    Identification and characterization of the human Gb3/CD77 synthase gene promoter (2008), Glycobiology, 18, 1028-1035.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.228 LPS
-
 Homo sapiens
2.4.1.228 TNF-alpha
-
 Homo sapiens
2.4.1.228 transcriptional factor Sp1
-
 Homo sapiens

Application

EC Number Application Comment Organism
2.4.1.228 medicine verotoxin induces endothelial cell death via the verotoxin receptor globotriaosylceramide, Gb3/CD77, leading to hemolytic uremic syndrome Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.228 the human Gb3S promoter is cloned and characterized Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.228 2-deoxy-D-glucose inhibits the Gb3S promoter activity in dose dependent manner Homo sapiens
2.4.1.228 mithramycin A inhibits the Gb3S promoter activity in dose dependent manner Homo sapiens
2.4.1.228 streptozotocin inhibits the Gb3S promoter activity in dose dependent manner Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.228 UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide Homo sapiens
-
 UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.228 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.228 endothelial cell endothelial cell surface Homo sapiens
-
2.4.1.228 HeLa cell
-
 Homo sapiens
-
2.4.1.228 kidney
-
 Homo sapiens
-
2.4.1.228 NCCIT cell
-
 Homo sapiens
-
2.4.1.228 SK-MEL-28 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.228 UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide
-
 Homo sapiens UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.228 alpha1,4-galactosyltransferase
-
 Homo sapiens
2.4.1.228 Gb3/CD77 synthase
-
 Homo sapiens
2.4.1.228 Gb3S
-
 Homo sapiens
2.4.1.228 lactosylceramide 4-alpha-galactosyltransferase
-
 Homo sapiens
2.4.1.228 lactosylceramide alpha1,4-galactosyltransferase
-
 Homo sapiens