Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Crawford, A.T.; Desai, D.; Gokina, P.; Basak, S.; Kim, H.A.
    E-cadherin expression in postnatal Schwann cells is regulated by the cAMP-dependent protein kinase A pathway (2008), Glia, 56, 1637-1647.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 dibutyryl-cAMP
-
 Rattus norvegicus
2.7.11.11 forskolin 0.005 mM for 48 h Rattus norvegicus
2.7.11.11 additional information not stimulated by glial growth factor, sensory and motor neuron derived factor, or platelet-derived growth factor Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 H-89
-
 Rattus norvegicus
2.7.11.11 myristoylated-PKI cAMP-PKA-specific inhibitory peptide PKI Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 additional information Rattus norvegicus cAMP elevation in the Schwann cell is sufficient to induce E-cadherin expression accompanied by suppression of N-cadherin expression ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 ganglion dorsal root ganglion Rattus norvegicus
-
2.7.11.11 Schwann cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + Kemptide
-
 Rattus norvegicus ADP + Kemptide phosphate
-
 ?
2.7.11.11 additional information cAMP elevation in the Schwann cell is sufficient to induce E-cadherin expression accompanied by suppression of N-cadherin expression Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 cAMP-PKA
-
 Rattus norvegicus
2.7.11.11 protein kinase A
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Rattus norvegicus
2.7.11.11 cAMP dependent Rattus norvegicus