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Literature summary extracted from

  • Bolin, C.; Cardozo-Pelaez, F.
    Characterization of oxidized guanosine 5-triphosphate as a viable inhibitor of soluble guanylyl cyclase (2009), Free Radic. Biol. Med., 46, 828-835.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 NO
-
 Rattus norvegicus
4.6.1.2 NO
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 8-oxoguanosine triphosphate i.e. oxo8GTP, a potent inhibitor of nitric oxide-stimulated soluble guanylyl cyclase Bos taurus
4.6.1.2 8-oxoguanosine triphosphate i.e. oxo8GTP, a potent competitive inhibitor of nitric oxide-stimulated soluble guanylyl cyclase Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 soluble
-
 Rattus norvegicus
-
-
4.6.1.2 soluble
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.2 Mg2+
-
 Rattus norvegicus
4.6.1.2 Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Rattus norvegicus
-
 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP Bos taurus
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Bos taurus
-
-
-
4.6.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 commercial preparation purified sGC from lung Bos taurus
-
4.6.1.2 lung
-
 Bos taurus
-
4.6.1.2 PC-12 cell adrenal medulla derived cell line Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP
-
 Bos taurus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 sGC
-
 Rattus norvegicus
4.6.1.2 sGC
-
 Bos taurus
4.6.1.2 soluble guanylyl cyclase
-
 Rattus norvegicus
4.6.1.2 soluble guanylyl cyclase
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.6.1.2 37
-
 assay at Rattus norvegicus
4.6.1.2 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.2 7.4
-
 assay at Rattus norvegicus
4.6.1.2 7.4
-
 assay at Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.6.1.2 additional information
-
 additional information inhibition kinetics Rattus norvegicus
4.6.1.2 additional information
-
 additional information inhibition kinetics Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.6.1.2 0.288
-
 pH 7.4, 37°C, in presence of 0.05 mM GTP Rattus norvegicus 8-oxoguanosine triphosphate
4.6.1.2 1.8
-
 pH 7.4, 37°C, in presence of 0.5 mM GTP Rattus norvegicus 8-oxoguanosine triphosphate