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Literature summary extracted from

  • Du, T.; Ciccotosto, G.D.; Cranston, G.A.; Kocak, G.; Masters, C.L.; Crouch, P.J.; Cappai, R.; White, A.R.
    Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation (2008), Free Radic. Biol. Med., 44, 44-55.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.3 buthionine sulfoximine
-
 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.3 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.3 ATP + gamma-L-glutamyl-L-cysteine + glycine Mus musculus the enzyme catalyzes the last step in glutathione biosynthesis, loss of intracellular neuronal GSH is an important feature of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, overview ADP + phosphate + glutathione
-
 ?
6.3.2.3 additional information Mus musculus the consequences of GSH depletion include increased oxidative damage to proteins, lipids, and DNA and subsequent cytotoxic effects. GSH is also an important modulator of cellular copper homeostasis and altered Cu metabolism is central to the pathology of several neurodegenerative diseases. Both neurons and fibroblasts revealed increased expression and activation of p53 after depletion of GSH ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.3 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.3 fibroblast
-
 Mus musculus
-
6.3.2.3 neuron primary cortical neurons Mus musculus
-
6.3.2.3 NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.3 ATP + gamma-L-glutamyl-L-cysteine + glycine
-
 Mus musculus ADP + phosphate + glutathione
-
 ?
6.3.2.3 ATP + gamma-L-glutamyl-L-cysteine + glycine the enzyme catalyzes the last step in glutathione biosynthesis, loss of intracellular neuronal GSH is an important feature of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, overview Mus musculus ADP + phosphate + glutathione
-
 ?
6.3.2.3 additional information the consequences of GSH depletion include increased oxidative damage to proteins, lipids, and DNA and subsequent cytotoxic effects. GSH is also an important modulator of cellular copper homeostasis and altered Cu metabolism is central to the pathology of several neurodegenerative diseases. Both neurons and fibroblasts revealed increased expression and activation of p53 after depletion of GSH Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.3 Glutathione synthetase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.3 ATP
-
 Mus musculus