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Literature summary extracted from

  • Whyteside, A.R.; Turner, A.J.
    Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences (2008), FEBS Lett., 582, 2382-2386.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B14 expression of both isoforms, NEP2 and NEP2DELTA Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B14 phosphoramidon approximately 8-fold more potent against neprilysin (EC 3.4.24.11) than neprilysin-2 Homo sapiens
3.4.24.B14 thiorphan far more potent against neprilysin (EC 3.4.24.11) than neprilysin-2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B14 membrane NEP2 exists as a membrane-bound and soluble enzyme, isoform NEP2DELTA exists as two membrane-bound glycoforms glycoforms, localised to the ER and plasma membrane Homo sapiens 16020
-
3.4.24.B14 soluble NEP2 exists as a membrane-bound and soluble enzyme Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B14 Homo sapiens Q495T6 soluble form, NEP2(s)
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B14 glycoprotein isoform NEP2DELTA exists as two membrane-bound glycoforms glycoforms, localised to the ER and plasma membrane Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B14 testis
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B14 angiotensin I + H2O hydrolyzed to 92% Homo sapiens ?
-
?
3.4.24.B14 bradykinin + H2O hydrolyzed to 57% Homo sapiens ?
-
?
3.4.24.B14 additional information neprilysin-2 shows a much restriceted substrate specificity compared to neprilysin Homo sapiens ?
-
?
3.4.24.B14 NEP fluorogenic substrate + H2O hydrolyzed to 39% Homo sapiens ?
-
?
3.4.24.B14 Substance P + H2O completely hydrolyzed Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B14 NEP2 NEP2 exists as two alternatively spliced isoforms, NEP2 and NEP2DELTA Homo sapiens
3.4.24.B14 NEP2(s) soluble Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.24.B14 0.000169
-
-
Homo sapiens phosphoramidon
3.4.24.B14 0.0221
-
-
Homo sapiens thiorphan