EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.B14 | expression of both isoforms, NEP2 and NEP2DELTA | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B14 | phosphoramidon | approximately 8-fold more potent against neprilysin (EC 3.4.24.11) than neprilysin-2 | Homo sapiens | |
3.4.24.B14 | thiorphan | far more potent against neprilysin (EC 3.4.24.11) than neprilysin-2 | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.B14 | membrane | NEP2 exists as a membrane-bound and soluble enzyme, isoform NEP2DELTA exists as two membrane-bound glycoforms glycoforms, localised to the ER and plasma membrane | Homo sapiens | 16020 | - |
3.4.24.B14 | soluble | NEP2 exists as a membrane-bound and soluble enzyme | Homo sapiens | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.B14 | Homo sapiens | Q495T6 | soluble form, NEP2(s) | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.24.B14 | glycoprotein | isoform NEP2DELTA exists as two membrane-bound glycoforms glycoforms, localised to the ER and plasma membrane | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.B14 | testis | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B14 | angiotensin I + H2O | hydrolyzed to 92% | Homo sapiens | ? | - |
? | |
3.4.24.B14 | bradykinin + H2O | hydrolyzed to 57% | Homo sapiens | ? | - |
? | |
3.4.24.B14 | additional information | neprilysin-2 shows a much restriceted substrate specificity compared to neprilysin | Homo sapiens | ? | - |
? | |
3.4.24.B14 | NEP fluorogenic substrate + H2O | hydrolyzed to 39% | Homo sapiens | ? | - |
? | |
3.4.24.B14 | Substance P + H2O | completely hydrolyzed | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.B14 | NEP2 | NEP2 exists as two alternatively spliced isoforms, NEP2 and NEP2DELTA | Homo sapiens |
3.4.24.B14 | NEP2(s) | soluble | Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.24.B14 | 0.000169 | - |
- |
Homo sapiens | phosphoramidon | |
3.4.24.B14 | 0.0221 | - |
- |
Homo sapiens | thiorphan |